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AOP4EUpest: Mapping of pesticides into Adverse Outcome Pathways using a text mining tool.
Choose an event and/or a chemical
All Events
Androgen receptor Antagonism
Cell death
Hepatotoxicity
Increase Vascular Resistance
MLL chromosomal translocation
Reproductive failure
Thyroxine (T4) in serum Decreased
Uncoupling eNOS
5α-reductase inhibition
7α-hydroxypregnenolone synthesis in the brain decreased
Aberrant Dendritic morphology
Abnormal Foraging activity and behavior
Abnormal Role change within caste
Abnormal Roll change within caste
Abnormal Sperm penetration (polyspermy)
Accelerated Aging
Accumulation Acetylcholine in synapses
Accumulation Biological membranes
Accumulation Collagen
Accumulation Damaged mitochondrial DNA
Accumulation Fatty acid
Accumulation Highly carboxylated porphyrins
Accumulation Liver lipid
Accumulation of misfolded proteins
Accumulation Triglyceride
Activate calmodulin
Activate GABA-A receptor
Activate leukocyte
Activate mucosal defense
Activate phospholipase
Activate PLC (Phospholipase C)
Activate presynaptic neuron 2
Activated gastric ulcer formation
Activated LXR
Activated membrane depolarization
Activated NMDA receptor
Activated presynaptic neuron 1
Activated voltage-gated sodium channel
Activation 3-hydroxy-3-methylglutaryl-CoA reductase gene
Activation 5-HT2A (Serotonin 2A)
Activation 5HT2c
Activation AhR
Activation AKT2
Activation Androgen receptor
Activation beta-2 adrenergic receptor
Activation Caspase 8 pathway
Activation ChREBP
Activation Constitutive androstane receptor
Activation Dendritic Cells
Activation EGFR
Activation Estrogen receptor
Activation estrogen receptor alpha
Activation FAS
Activation Fibroblasts
Activation FOXO
Activation Glucocorticoid Receptor
Activation Glutamate-gated chloride channel
Activation Glutamate-gated chloride channels
Activation Hepatic nuclear receptor(s)
Activation HIF-1
Activation Inflammatory cytokines chemokines cytoprotective gene pathways
Activation ionotropic GABA Receptor chloride channel
Activation JAK/STAT pathway
Activation JNK
Activation Juvenile hormone receptor
Activation Keratinocytes
Activation Latent Transforming Growth Factor Beta 1
Activation Long term AHR receptor driven direct and indirect gene expression changes
Activation LXR
Activation LXR alpha
Activation Macrophages
Activation MTTP
Activation Muscarinic Acetylcholine Receptors
Activation NADPH Oxidase
Activation Nicotinic acetylcholine receptor
Activation NR1H4
Activation NRF2
activation of CCAAT/enhancer-binding protein alpha
Activation of Cyp2E1
Activation of hepatic stellate cells
Activation of specific nuclear receptors Transcriptional change
Activation of TGF-β signaling
Activation PPARα
Activation Pregnane-X receptor NR1l2
Activation PTGS-1 (Prostaglandin-endoperoxide synthase 1)
Activation PTGS-2 (Prostaglandin-endoperoxide synthase 2)
Activation PXR/SXR
Activation SCD-1
Activation SHP
Activation Sp1
Activation SREBF1
Activation SREBP-1c
Activation Stellate cells
Activation TGF-beta pathway
Activation Tissue resident cells (Kuppfer cells)
Activation Transforming Growth Factor beta pathway
Activation/Proliferation T-cells
Acute inhalation toxicity
Agonism Androgen receptor
Agonism Estrogen receptor
Airway epithelial injury
Alkylation DNA
Alkylation Protein
Alteration Food-web structures
Alteration lipid metabolism
Alteration Wnt pathway
Alterations Cellular proliferation / hyperplasia
Altered Action Potential
Altered Amphibian metamorphosis
Altered Ca2+-calmodulin activated signal transduction
Altered Cardiovascular development/function
Altered Chromosome number
Altered Chromosome number (polyploid) zygote
Altered differentiation
Altered Formation of cortical envelope
Altered Gene Expression
Altered gene expression specific to CAR activation Hepatocytes
Altered Larval development
Altered Meiotic chromosome dynamics
Altered Neuroanatomy
Altered Neurophysiology
Altered Protein Production
Altered regulation Alpha hemoglobin
Altered Reproductive behaviour
Alveolar collapse
Alveolar reopening
Analgesia
Antagonism Estrogen receptor
Antagonism Histamine Receptor (H2)
Antagonism Thyroid Receptor
Anti-depressant Activity
Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone Impairment of post-translational modification (carboxylation) of osteo
Apoptosis
Apoptosis of adult Leydig cells Decreased testosterone by adult Leydig cells
Bile accumulation Pathological condition
Binding at picrotoxin site iGABAR chloride channel
Binding of agonist Ionotropic glutamate receptors
Binding of antagonist NMDA receptors
Binding of antagonist PPAR alpha
Binding of inhibitor NADH-ubiquinone oxidoreductase (complex I)
Binding of inhibitor to mitochondrial complex III
Binding of inhibitor to mitochondrial complex IV
Binding of inhibitor to mitochondrial complex V
Binding of microtubule stabilizing agents (MSA) to microtubules
Binding of substrate endocytic receptor
Binding Thiol/seleno-proteins involved in protection against oxidative stress
Binding to (interferes with) topoisomerase II enzyme
Binding Transthyretin in serum
Binding Tubulin
Blockade L-Type Calcium Channels
Blocking of IL-1R
Blood extravasation into the lungs
Blood loss and development of anemia Impaired oxygen delivery and nutrient delivery to tissue impaired carbon dioxide and waste product removal
Breast Cancer
Bronchiolitis obliterans
Cancer Malignancy
cell cycle disrupted
Changes/Inhibition Cellular Homeostasis and Apoptosis
Chemical induced Fanconi syndrome
Cholestasis Pathology
chronic high fat diet
Chronic kidney disease
Chronic Mucus hypersecretion
Clonal Expansion/Cell Proliferation to form Altered Hepatic Foci (AHF)
Cognitive Function Decreased
Collagen Deposition
Collagen production reduced
Covalent Binding Protein
Covalent binding to protein possibly lysine residue
Cyanosis occurs
CYP2E1 Activation
CYP7B activity inhibition
Damage Lipid bilayer
Damaging Mitochondria
Damaging Red blood cells
Death/Failure Colony
Decline Population
Decompartmentalization
Decrease Abdominal muscle contraction
Decrease androgen receptors (AR) activation
Decrease Apoptosis of ciliated epithelial cells
Decrease Bioactivation of testosterone
Decrease Calcium binding to Troponin C
Decrease Calcium currents
Decrease Cardiac contractility
Decrease Cardiac ejection fraction
Decrease Chlorophyll synthesis
Decrease Chloroplast ATP production
Decrease Circulating crustacean cardioactive peptide
Decrease Circulating ecdysis triggering hormone
Decrease Cuticular chitin synthesis
Decrease dihydrotestosterone (DHT) level
Decrease E2 blood concentrations at hypothalamus
Decrease Ecdysis motoneuron bursts
Decrease Excitatory postsynaptic potential
Decrease Fecundity
Decrease Fertility
Decrease Glycolysis
Decrease Growth
Decrease GTPCH-1
Decrease histaminergic neuron excitation
Decrease in mitochondrial oxidative phosphorylation
Decrease Incorporation of active iodide into iodotyrosines
Decrease Intracellular pH
Decrease Leaf cell mitosis
Decrease Leaf development
Decrease leukocyte adherence
Decrease Light harvest capacity
Decrease Lung function
Decrease Mitochondrial ATP production
Decrease Number of worker bees
Decrease of GABAergic interneurons
Decrease of neuronal network function
Decrease of synaptogenesis
Decrease of Thyroidal iodide
Decrease Oogenesis
Decrease Ovulation
Decrease Oxidative phosphorylation
Decrease Photosynthesis
Decrease Photosystem II activity
Decrease Population trajectory
Decrease Serum thyroid hormone (T4/T3)
Decrease Steroidogenic acute regulatory protein (STAR)
Decrease surfactant
Decrease testosterone synthesis/level
Decrease Tetrahydrobiopterin
Decrease Transgenerational DNA methylation
Decrease Translocator protein (TSPO)
Decreased 3-hydroxyacyl-CoA dehydrogenase type-2 activity
Decreased 5-HT3
Decreased Androgen receptor activity
Decreased angiogenesis
Decreased anxiety
Decreased Apoptosis (Epithelial Cells)
Decreased Aromatase (Cyp19a1) mRNA
Decreased bicarbonate
Decreased bile flow
Decreased Binding of NE to NE receptors on GnRH neurons
Decreased Body Weight
Decreased Calcium influx
Decreased cholesterol
Decreased Cholesterol Decreased De Novo Biosynthesis of Choleseterol
Decreased Cholesterol Decreased sperm quantity and/or quality in the adult testis
Decreased Cholesterol Decreased Testosterone Production by Adult Leydig Cells
Decreased Cholesterol Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
Decreased Cholesterol Decreased Uptake of Lipoproteins
Decreased Cortical granule release/distribution upon fertilization
Decreased Decreased fecundity
Decreased DHB4/HSD17B4
decreased DNA methylation of tyrosine hydroxylase
decreased dopamine
Decreased Dopaminergic activity
Decreased extracellular chloride (Cl-)
Decreased extracellular serotonin
Decreased extracellular sodium (Na+)
Decreased fertility in the adult Decreased sperm quantity and/or quality in the adult testis
Decreased fertility Reduced number of oocytes ovulated
Decreased GABA
Decreased GABA release
Decreased Glomerular filtration
Decreased Glucose oxidase enzyme activity
Decreased GnRH cfos activity
Decreased GnRH pulsatility/release
Decreased GnRH pulsatility/release in hypothalamus
Decreased GnRH Release Decreased Kisspeptin stimulation of GnRH neurons
Decreased HSD17B10 expression
Decreased Hydrogen peroxide production
Decreased IL-1 production
Decreased intracellular chloride
Decreased intracellular serotonin
Decreased Ketogenesis
Decreased Ketogenesis (production of ketone bodies)
Decreased Kisspeptin release from neurons in AVPV Decreased hypothalamic estrogen reduces kisspeptinergic neuron response
Decreased LH release from Anterior Pituitary Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs
Decreased LH Surge
Decreased LH Surge from anterior pituitary
Decreased locomotion
Decreased Long-term potentiation (LTP)
Decreased Lymphocytes
decreased methylation of dopamine transporter promoter
Decreased mevalonate
Decreased Mitochondrial fatty acid beta-oxidation
Decreased mucosal blood flow
Decreased mucous
Decreased Na/K ATPase activity
Decreased Neuronal network function in adult brain
Decreased neuroplasticity
Decreased Nitric Oxide
Decreased number and function of adult Leydig cells Decreased COUP-TFII stem Leydig cells
Decreased optical elements of the eye
Decreased Ovarian E2
Decreased packaged serotonin
Decreased PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
Decreased plasma RA level
Decreased population 1
Decreased Population trajectory
Decreased positive estrogenic feedback on hypothalamus Reduced estradiol in circulation decreases estrogen concentration at hypothalamus
Decreased PPAR-alpha activation
Decreased PPAR-beta activation
Decreased PPAR-gamma activation
Decreased PPARalpha transactivation of gene expression
Decreased Progesterone from corpus luteum
Decreased Prolactin
Decreased Prostaglandin F2alpha concentration plasma
Decreased Prostaglandin F2alpha synthesis ovary
Decreased protection against oxidative stress
Decreased proximal tubular vectorial transport
Decreased Renal ability to dilute urine
Decreased Renal plasma flow
Decreased Reproductive Success
Decreased retinoic acid (RA) synthesis
decreased reward
Decreased serotonin transporter activity
Decreased serum T4/T3
Decreased sheltering
Decreased Sodium conductance 1
Decreased sodium conductance 2
Decreased Sodium reabsorption
Decreased sperm quantity / quality in the adult Decreased fertility
Decreased sperm quantity or quality in the adult Decreased fertility
Decreased steroidogenesis Alterations in the Leydig Cell Cytoskeleton
Decreased steroidogenesis Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells
Decreased steroidogenesis Increased Apoptosis of Adult Leydig Cells
Decreased steroidogenesis Proteomic alterations in the adult Leydig cell
Decreased survival
Decreased synaptic release
Decreased Synthesis of NE
Decreased Testosterone
Decreased Testosterone binding to androgen receptor (hypothalamus)
decreased testosterone by fetal Leydig cells Dysgenesis of fetal Leydig cells
Decreased testosterone by the fetal Leydig cells Activation by other estradiol agonists
Decreased testosterone by the fetal Leydig cells Activation by other glucocorticoid receptor agonists
Decreased testosterone by the fetal Leydig cells Alterations in the fetal testis proteome
Decreased testosterone by the fetal Leydig cells Decreased COUP-TFII stem Leydig cells
Decreased testosterone by the fetal Leydig cells Dysgenesis of fetal Leydig cells
Decreased testosterone by the fetal Leydig cells Dysgensis of fetal Leydig cells
Decreased testosterone by the fetal Leydig cells Hypermethylation in the fetal testis
Decreased testosterone by the fetal Leydig cells Increased corticosterone
Decreased testosterone by the fetal Leydig cells Increased COUP-TFII in fetal Leydig cells
Decreased testosterone by the fetal Leydig cells Increased estradiol
Decreased Thyroxine (T4) in serum
Decreased Thyroxine (T4) in tissues
Decreased Transcription of genes by AR
Decreased Triiodothyronine (T3) in serum
Decreased Triiodothyronine (T3) in tissues
Decreased Uptake of inorganic iodide
Defect of Embryogenesis
Degeneration of dopaminergic neurons of the nigrostriatal pathway
Delayed Ovulation
Depletion energy reserves
Depletion mtDNA
Depletion Nitric Oxide
Desensitization Nicotinic acetylcholine receptor
dimerization AHR/ARNT
Direct effects of Corticosterone on steroidogenesis Decreased testosterone by adult Leydig cells
Direct mitochondrial inhibition
Disorganization Spindle
Displacement Serum thyroxine (T4) from transthyretin
Disruption Intracellular calcium mobilization
Disruption Lysosome
Disruption Membrane integrity
Disruption Microtubule dynamics
Disruption Mitochondrial electron transport chain
Disruption of lung surfactant function
Disruption Sarcomere assembly
Disturbance in microtubule dynamic instability
Disturbance Lysosomal function
DNA double-strand break
Dopamine release in the brain decreased
Down Regulation CPT1A
Down Regulation GSS and GSTs gene
Down Regulation Gulcose-6-phosphate dehydrogenase
Down Regulation HMGCS2
Dysfunction Mitochondria
Endocytotic lysosomal uptake
Epithelial-mesenchymal transition induced
Facial cartilage structures are reduced in size and morphologically distorted
Failure in gamma-glutamyl carboxylation of clotting factors II VII IX and X Under carboxylation of clotting factors (e.g. des-gamma-carboxy prothromb
Failure in vascular repair mechanisms Unresolved blood loss (hemorrhage)
Fatty Acid Beta Oxidation Decreased
Feminisation or incomplete development Primary and accessory male sex organs
Fibroproliferative airway lesions
Foam cell formation
Formation Hepatocellular and Bile duct tumors
Formation Liver fibrosis
Formation Liver tumor
Formation Mallory body
Formation of HDL-SAA
Formation of hemoglobin adducts
Formation Pro-mutagenic DNA Adducts
Frizzled activation
Frustrated phagoytosis
General Apoptosis
Generation Amplified excitatory postsynaptic potential (EPSP)
Glucocorticoid Receptor Agonist Activation
Glucocorticoid Receptor mediated alterations in steriodogenic enzymes Decreased testosterone by adult Leydig cells
Glutamate dyshomeostasis
Glutathione homeostasis
Glutathione synthesis
Growth reduction
GSK3beta inactivation
Heart failure
Helicobacter pylori infection
Hemostasis Depletion from blood of fully functional carboxylated clotting factors
Hepatocytotoxicity
Hepatotoxicity
Hippocampal anatomy Altered
Hippocampal gene expression Altered
Hippocampal Physiology Altered
Histone acetylation increase
Histone deacetylase inhibition
Hyperplasia
Hyperplasia Leydig cell
Hyperplasia Mammary gland
Hyperplasia ovarian epithelium
Hyperplasia ovarian stromal cells
hyperpolarisation neuron
Hypertension
Hypertrophy/hyperplasia smooth muscle
hypoxia
Impaired Ab production
Impaired axonial transport
impaired Development
Impaired development of Reproductive organs
impaired Fertility
impaired Hive thermoregulation
Impaired IL-1 signaling
Impaired inguinoscrotal testicular descent phase
impaired ion channels
impaired Larval development
Impaired oxygenation of the blood
Impaired Proteostasis
Impaired recruitment Population trajectory
Impaired T cell activation
Impaired Vasodilation
Impairedanterior-posterior axis development
Impairment Endothelial network
Impairment Learning and memory
Impairment of reproductive capacity
Impairment T-cell dependent antibody response
Inactivated 5-HTR (serotonin receptors)
Inactivation of PPARγ
Inactive membrane depolarization
Inadequate DNA repair
Increase Adenomas/carcinomas (bronchioloalveolar)
Increase Adenomas/carcinomas (follicular cell)
Increase Adenomas/carcinomas (hepatocellular)
Increase Adenomas/carcinomas (renal tubular)
Increase Adenomas/carcinomas (urothelial)
Increase Allergic Respiratory Hypersensitivity Response
Increase ammonium (NH4+)
Increase Aneuploid offspring
Increase angiogenesis
Increase Apoptosis
Increase bicarbonate
Increase Biliary excretion TH glucuronide
Increase Ca++ (intracellular)
Increase Cancer
Increase Cell membrane depolarization
Increase Cell Proliferation
Increase Cell Proliferation (Epithelial Cells)
Increase Chitin synthase inhibition
Increase Chromosomal aberrations
Increase cilia movement
Increase Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci
Increase cortisone
Increase COX-2 expression
Increase cytosolic fatty acid
Increase Cytotoxicity
Increase Cytotoxicity (club cells)
Increase Cytotoxicity (corneal cells)
Increase Cytotoxicity (epithelial cells)
Increase Cytotoxicity (hepatocytes)
Increase Cytotoxicity (renal tubular cell)
Increase Cytotoxicity (tubular epithelial cells)
Increase Cytotoxicity (urothelial cells)
Increase D1 protein blockage
Increase Differentiation of fibroblasts
Increase DNA damage
Increase DNA hypomethylation
Increase DNA methyltransferase inhibition
Increase DNA strand breaks
Increase Dopaminergic activity
Increase Early Life Stage Mortality
Increase Ecdysone receptor agonism
Increase Endometrial adenocarcinomas
Increase Energetic demands and therefore metabolic stress
Increase FA Influx
Increase Follicular atresia
Increase Fushi tarazu factor-1 gene expression
Increase GABA
Increase Gene expression
Increase Growth inhibition
Increase Heritable mutations in offspring
Increase Hyperplasia (follicular cells)
Increase Hyperplasia (forestomach epithelial cells)
Increase Hyperplasia (glandular epithelial cells of endometrium)
Increase Hyperplasia (Leydig cells)
Increase Hyperplasia (renal tubular cells)
Increase Hyperplasia (terminal bronchiolar cells)
Increase Hyperplasia (tubular epithelial cells)
Increase Hyperplasia (urothelial)
Increase hypertension
Increase Hypertrophy and proliferation (follicular cell)
Increase in reactive oxygen and nitrogen species (RONS)
Increase Incomplete ecdysis
Increase Increased susceptibility to infection
Increase Inflammation
Increase Inflammation (corneal cells)
Increase inositol triphosphate
Increase intracellular calcium
Increase leukocyte adherence
Increase Leydig cell tumors
Increase Liver and splenic hemosiderosis
Increase Luteinizing hormone (LH)
Increase Mitogenic cell proliferation (hepatocytes)
Increase Mortality
Increase Mucin production
Increase mucosal blood flow
Increase mucous
Increase Mutations
Increase Mutations in Critical Genes
Increase myosin light chain phosphorylation
Increase Necrosis
Increase Necrosis (terminal bronchiolar cells)
Increase Nuclear receptor E75b gene expression
Increase Opening of voltage-dependent calcium channel
Increase Oxidative damage to DNA
Increase Oxidative DNA damage
Increase Oxidative metabolism
Increase Oxidative Stress / Activation PMK-1 P38 MAPK
Increase Papillomas/carcinomas (squamous cells)
Increase Plasma vitellogenin concentrations
Increase platelet aggregation
Increase predation
Increase Premature molting
Increase Preneoplastic foci (hepatocytes)
Increase proinflammatory mediators (TNFalpha)
Increase proliferation Leydig cell
Increase Proliferation of goblet cells
Increase RBC congestion in liver
Increase Reactive oxygen species
Increase Reactive oxygen species production
Increase Regenerative cell proliferation (corneal cells)
Increase Regenerative cell proliferation (forestomach epithelial cells)
Increase Regenerative cell proliferation (hepatocytes)
Increase Regenerative cell proliferation (terminal bronchiolar epithelial cells)
Increase Regenerative cell proliferation (tubular epithelial cells)
Increase Regenerative cell proliferation (urothelial cells)
Increase Renal pathology due to VTG deposition
Increase Respiratory or Squamous Metaplasia
Increase S-adenosylmethionine depletion
Increase seizure
Increase Site of Contact Nasal Tumors
Increase Sulfonylurea receptor binding
Increase surfactant
Increase Thyroid-stimulating hormone (TSH)
Increase Tissue Degeneration Necrosis & Atrophy
Increase Uncoupling of oxidative phosphorylation
Increase Uncoupling of photophosphorylation
Increase Urinary bladder calculi
Increase vascular smooth muscle contraction
Increase Vitellogenin synthesis in liver
Increased 5-HT3 (5-hydroxytryptamine)
Increased Accumulation of alpha2u microglobulin (proximal tubular epithelium)
Increased activation of T (T) helper (h) type 2 cells
Increased activity beta-2 adrenergic receptor
Increased adenomas (pituitary)
Increased Adenomas/carcinomas (mammary)
Increased adenosquamous carcinomas of endometrium
Increased adipogenesis
Increased agitation
Increased amputations
Increased Angiogenesis
Increased ApoB100
Increased Apoptosis Adenomas/carcinomas (follicular cell)
Increased apoptosis decreased number of adult Leydig Cells
Increased Appetite and hunger
Increased Ataxia paralysis or hyperactivity
Increased Atrioventricular block and bradycardia
Increased Binding of chemicals to 2u (serum)
Increased blood potassium concentration
Increased blood uric acid concentration
Increased cardiac arrthymia
Increased Catabolism of Muscle Protein
Increased Cell Proliferation (mesothelium)
Increased Cellular proliferation / hyperplasia of acinar cells
Increased CGRP neuronal release of CGRP
Increased Chloride conductance
Increased cholestasis
Increased Chromosome misseggregation
Increased circulating estrogen levels
Increased Clearance of thyroxine from tissues
Increased cyclic adenosine monophosphate
Increased De Novo FA synthesis
Increased Deformed Wing Virus levels
Increased depression
Increased Developmental Defects
Increased Disease susceptibility
Increased DNA damage and mutation
Increased DNA Damage-Repair
Increased Ductal Hyperplasia
Increased Energetic demands and therefore metabolic stress
Increased epilepsy
Increased ER binding to DNA (classical pathway)
Increased ER binding to T.F. to DNA (non-classical pathway)
Increased Estrogen receptor (ER) activity
Increased extracellular matrix deposition
Increased extracellular serotonin
Increased FA Influx
Increased fibroblast proliferation and myofibroblast differentiation
Increased Firbrosarcoma
Increased foot detachment
Increased Free serum thyroxine (T4)
Increased glomerular rupture and renal hemorrhaging
Increased glucocorticoid receptor activity
Increased glutamate
Increased hemagiosarcoma
Increased Hepatic thyroid hormone uptake/transport
Increased HIF-1 alpha transcription
Increased HIF-1 heterodimer
Increased hippocampal hyperdepolarization
Increased Homocysteine level
Increased Hyperplasia (follicular cells)
Increased Hyperplasia (glandular epithelial cells of endometrium)
Increased hyperplasia (mammary gland)
Increased Hypertrophy and proliferation (follicular cell)
Increased IGF-1 (mouse)
Increased Induced Mutations in Critical Genes
Increased Induction of pyruvate dehydrogenase (PDH)
Increased induction of UDPGT's in liver
Increased inflammation
Increased Inhibitory postsynaptic potential
Increased Insufficient repair or mis-repair of pro-mutagenic DNA adducts
Increased interaction with the resident cell membrane components
Increased Intracellular Calcium overload
Increased intracellular chloride (Cl-)
Increased intracellular serotonin
Increased intracellular sodium (Na+)
Increased Invasion
Increased Kidney Failure
Increased lactotroph hyperplasia and hypertrophy
Increased latency period
Increased LDL uptake
Increased leukocyte activation
Increased leukocyte adherence
Increased Leutinizing hormone (LH)
Increased liposarcoma
Increased Liver Steatosis
Increased locomotion
Increased loss of alveolar capillary membrane integrity
Increased Luteinizing hormone (LH)
Increased Male offspring
increased mantel display
Increased mesotheliomas
Increased Migration (Endothelial Cells)
Increased Mortality
Increased Motility
Increased muscular waves in foot
Increased nephropathy
Increased neurokinin A (NKA) by neuronal cells
Increased Neuronal synaptic inhibition
Increased Non-genomic signaling
Increased Oncotic Necrosis
Increased oocyte maturation
Increased Oxidative damage
Increased Oxidative Stress
Increased packaged serotonin
Increased Pancreatic acinar tumors
Increased Plasma HCY level
Increased Plasma tyrosine
Increased Population
Increased PPAR-alpha activation
Increased predation
Increased Pro-inflammatory mediators
Increased production of pulmonary pro-inflammatory cytokines
Increased production of pulmonary SAA
Increased prolactin exposure
Increased prolactin secretion
Increased Proliferation (Endothelial cells)
Increased proliferation of mesenchymal cells
Increased RDX dose
Increased Reactive oxygen species
Increased reactive oxygen species (in the mitochondria)
Increased recruitment of inflammatory cells
Increased renal vitellogenin deposition
Increased Reproductive Success
Increased Respiratory distress/arrest
Increased Respiratory irritability and Chronic Cough
Increased Second Messenger Production
Increased secrection of FSH from anterior pituitary
Increased secretion of GnRH from hypothalamus
Increased secretion of LH from anterior pituitary
Increased secretion of local growth factors
Increased secretion of proinflammatory and profibrotic mediators
Increased seizure
Increased serotonin (5-HT)
Increased serotonin transporter activity
Increased Serum creatinine
Increased steatosis
Increased synaptic release
Increased systemic total cholesterol pool
Increased T4/T3 catabolism
Increased Thyroid-stimulating hormone (TSH)
Increased Triglyceride
Increased Triglyceride formation
Increased Triiodothyronine (T3) in tissues
Increased Uptake of thyroxine into tissue
Increased valve movement
Increased Viral susceptibility
Increased visual impairment
Increased Vitellogenin synthesis
Increased water retention in foot
Induced dysfunction of microcirculation
Induced parturition
induced spawning
Induction Ataxia paralysis or hyperactivity
Induction CYP1A2/CYP1A5
Induction Doublesex1 gene
Induction Epithelial Mesenchymal Transition
Induction IKB inhibitory protein
Induction Liver “Dysfunctional” Changes by CGA 330050
Induction Male reproductive tract
Induction Microvesicular fat
Induction pharyngeal muscle paralysis
Induction Somatic muscle paralysis
Induction Sustained Cell Proliferation
Induction Sustained Hepatotoxicity
Induction Upregulation of glucuronyltransferase activity
Infant leukaemia
Inflamatory events in light-exposed tissues
Inhibit gastric ulcer formation
Inhibit serotonin transporter activity
Inhibit voltage-gated sodium channel
Inhibition 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
Inhibition 5-hydroxytryptamine transporter (5-HTT
Inhibition 5α-reductase activity
Inhibition Acetylcholinesterase (AchE)
Inhibition Antgonism of NE receptor
Inhibition Aromatase
Inhibition Bile Salt Export Pump (ABCB11)
Inhibition Ca++ ATPase
Inhibition Calcineurin Activity
Inhibition Cyclooxygenase 1 activity
Inhibition Cyclooxygenase activity
Inhibition Cytochrome P450 enzyme (CYP17A1) activity
Inhibition Deiodinase 1
Inhibition Deiodinase 2
Inhibition Deiodinase 3
Inhibition Dual oxidase
Inhibition Ether-a-go-go (ERG) voltage-gated potassium channel
Inhibition Fatty Acid Beta Oxidation
Inhibition Feeding
Inhibition FoxA2
Inhibition HMG-CoA reductase
Inhibition IKK complex
Inhibition Inducible Nitric Oxide Synthase by Metabolite CGA 265307
Inhibition Inhibition of Dopamine-beta-hydroxylase
Inhibition Iodotyrosine deiodinase (IYD)
Inhibition Mitochondrial fatty acid beta-oxidation
Inhibition Na+/I- symporter (NIS)
Inhibition NADH-ubiquinone oxidoreductase (complex I)
Inhibition NMDARs
Inhibition Nuclear factor kappa B (NF-kB)
Inhibition of Aromatase Enzyme Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversio
Inhibition of cystathionine beta-synthase
Inhibition of lysyl oxidase
Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
Inhibition of N-linked glycosylation
Inhibition of N-type Ca ion channels
Inhibition of neurotransmitter vesicle release
Inhibition of tyrosinase
Inhibition organic anion transporter 1 (OAT1)
Inhibition Pendrin
Inhibition Phospholipase A
Inhibition PPAR alpha
Inhibition Prolyl hydroxylases
Inhibition PTGS-1 (Prostaglandin-endoperoxide synthase 1)
Inhibition PTGS-2 (Prostaglandin-endoperoxide synthase 2)
Inhibition Pyruvate dehydrogenase kinase (PDK) enzyme
Inhibition sodium channel
Inhibition SREBP1c
Inhibition UROD
Inhibition VegfR2
Inhibition Wnt pathway
Injury Mitochondria
Insufficiency Vascular
Interaction of α-diketones with arginine residues
Interference nuclear localization of NFAT
interruption Ovulation
irregularities ovarian cycle
Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139 Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinon
Irritation of nasal mucosa inducing sneeze reflex
KE5 : Decrease AKT/eNOS activity
Leukocyte recruitment/activation
Lipid Peroxidation
Liver Cancer
Liver fibrosis
Liver Injury
Liver Steatosis
Locomotor activity decreased
Loss Cochlear function
Loss of barrier function
Lung cancer
Lung fibrosis
Malformation cryptorchidism - maldescended testis
Malformation Male reproductive tract
malformed Male reproductive tract
Metabolism of AFB1 Production of Reactive Electrophiles
Methemoglobinemia decreased hemoglobin hematocrit red blood cell number
Mitochondrial Complex III inhibition
Mitochondrial Complex IV inhibition
Mitochondrial Complex V inhibition
Mitochondrial dysfunction 1
Mitochondrial impairment
Mitochondrial Injury
modulation Extracellular Matrix Composition
modulation Genes/proteins that regulate hepatocyte fate
modulation sodium channel
Mu Opioid Receptor Agonism
N/A Ataxia paralysis or hyperactivity
N/A Steatohepatisis
narcosis
Necrosis
Necrotic Tissue
Neural crest cell migration reduced
Neural tube defects
Neurodegeneration
Neuroinflammation
NFE2/Nrf2 repression
Not Increased Circulating Ketone Bodies
Notochord distortion or malformations
obesity
Occurrence A paroxysmal depolarizing shift
Occurrence Ballooning degeneration (hepatocyte)
Occurrence cardiac arrhythmia
Occurrence Cellular Seizure
Occurrence Cystic dilatation (renal tubule)
Occurrence Cytoplasmic vacuolization (Bile duct cell)
Occurrence Cytoplasmic vacuolization (hepatocyte)
Occurrence Cytoplasmic vacuolization (kupffer cell)
Occurrence Cytoplasmic vacuolization (podocyte)
Occurrence Cytoplasmic vacuolization (Renal tubule)
Occurrence Epileptic seizure
Occurrence Hyperplasia of goblet cells
Occurrence Kidney toxicity
Occurrence Metaplasia of goblet cells
Occurrence renal ischemia
Occurrence renal proximal tubular necrosis
Occurrence tophi (urate) deposition
Occurrence Transdifferentiation of ciliated epithelial cells
Opening of calcium channel Calcium influx
Opening of G protein gated inward rectifying K channels
Osteoporosis and vascular calcification Bone deterioration
Overactivation muscle contraction
Overactivation Neuronotransmitter release
Overactivation NMDARs
Overwhelmed Mitochondrial DNA repair mechanisms
Ovulation of oocytes Reduced Delayed or Blocked Decrease or delay in LH surge required for ovulation
Oxidation Glutathione (To be considered with MIE)
Oxidation of membrane lipids
Oxidation Uroporphyrinogen
Oxidation/denatuation of membrane proteins
Oxidative Stress
Oxidative Stress in Brain
p21 (CDKN1A) expression increase
Parkinsonian motor deficits
Peptide Oxidation
peroxisome proliferator activated receptor promoter demethylation
persistent cytotoxicity (pleura or peritoneum)
Perturbation of cholesterol
Plaque progression in arteries
PPAR-gamma activation
prepubertal increase Estrogen receptor (ER) activity
Production Critical Metabolites (CGA 330050 and CGA 265307)
Production Reactive oxygen species
Proliferation Cell proliferation in the absence of cytotoxicity
Proliferation/Clonal Expansion aberrant basal cells
Proliferation/Clonal Expansion smooth muscle
prolonged Depolarization of neuronal membrane
prolonged elevation of serun CCK
prolonged estrus
Promotion Hepatocelluar carcinoma
Promotion mesovarian leiomyomas
Promotion ovarian adenomas
Promotion ovarian granular cell tumors
Promotion SIX-1 postive basal-type progenitor cells
Propagation Oxidative stress
Proteasomal dysfunction
Protein Adduct Formation
Pulmonary fibrosis
Reduce expression BDNF (Brain-derived neurotrophic factor)
Reduced Ability to attract spawning mates
Reduced Anterior swim bladder inflation
Reduced Antiseptic incorporated in food
Reduced BDNF (Brain-derived neurotrophic factor)
Reduced Brood care
reduced dimerization ARNT/HIF1-alpha
Reduced Estradiol in Circulation Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation
Reduced fatty acid beta oxidation
Reduced feeding 1
Reduced fitness or even mortality Acidosis hypovolemic shock and organ dysfunction
Reduced Food storage
Reduced FXR activity
Reduced GABA-A receptor activation
Reduced Gonadotropin releasing hormone hypothalamus
Reduced Hearing
Reduced HSD17B4 activity
Reduced levels of BDNF
Reduced lung volume
Reduced Luteinizing hormone (LH) plasma
Reduced Maturation inducing steroid plasma
Reduced Maturation inducing steroid receptor signalling oocyte
Reduced Meiotic prophase I/metaphase I transition oocyte
Reduced mucosal defense
Reduced Pheromone release
Reduced platelet aggregation
Reduced Posterior swim bladder inflation
Reduced PPARalpha
Reduced presynaptic neuron 2 activity
Reduced Presynaptic release of glutamate
reduced production VEGF
Reduced Prostaglandin E2 concentration hypothalamus
Reduced Prostaglandin F2alpha concentration plasma
Reduced Prostaglandin F2alpha synthesis ovary
Reduced Prostaglandins ovary
Reduced PTGS1 function
Reduced PTGS2 function
Reduced Reproductive Success
Reduced SHP activity
Reduced Spawning behavior
Reduced survival
Reduced Swimming performance
Reduced swimming speed
Reduced Young of year survival
Reduction 17-OH-pregnenolone conversion in DHEA
Reduction 17-OH-progesterone conversion in androstenedione
Reduction 17beta-estradiol synthesis by ovarian granulosa cells
Reduction Angiogenesis
Reduction Ca and HCO3 transport to shell gland
Reduction Cholesterol transport in mitochondria
Reduction Cumulative fecundity and spawning
Reduction Eggshell thickness
Reduction fo Pigmentation pattern
Reduction Gonadotropins circulating concentrations
Reduction in melanin level
reduction in ovarian granulosa cells Aromatase (Cyp19a1)
reduction in ovarian granulosa cells synthesis of estradiol Reduced steroidogenic production of estradiol in granulosa cells
Reduction Ionotropic GABA receptor chloride channel conductance
Reduction Neuronal synaptic inhibition
Reduction NFAT/AP-1 complex formation
Reduction of collagen crosslinking
Reduction of L-Dopaquinone
Reduction of melanosome level
Reduction Plasma 17beta-estradiol concentrations
Reduction Plasma vitellogenin concentrations
Reduction Prostaglandin E2 concentration
Reduction testosterone level
Reduction Testosterone synthesis by ovarian theca cells
Reduction Testosterone synthesis in Leydig cells
Reduction Vitellogenin accumulation into oocytes and oocyte growth/development
Reduction Vitellogenin synthesis in liver
Regenerative Proliferation
relaxation smooth muscle
Release Cytokine
Release of G Proteins
Repress GABA-A receptor
Repressed expression of steroidogenic enzymes
Reproductive failure
Retinaldehyde dehydrogenase inhibition
ROS formation
ROS generation from photoactivated chemicals
S-Glutathionylation eNOS
sedation
Sensing of the stressor by pulmonary cells
sensitisation skin
Sensory axonal peripheral neuropathy
Serotonin 1A Receptor Agonism
Sexual behavior decreased
skewed sex ratio
Snail Zeb Twist activation
SP (Substance P) release Local increase of SP
spermatocyte depletion
squamous metaplasia aberrant basal cells
stabilization PPAR alpha co-repressor
Stimulation of adult Leydig cells via the Adrenal Corticosterone Increased Glucocorticoid
Substance - lung surfactant interaction
Suppression Constitutive androstane receptor NR1l3
Suppression Estrogen receptor (ER) activity
Suppression HNF4alpha
Suppression IL-2 and IL-4 production
Suppression Immune system
Suppression Inflammatory cytokines
Suppression VLDL secretion
Synthesis De Novo FA
systemic inflammation leading to hepatic steatosis
testicular toxicity
Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
Thyroid hormone synthesis Decreased
Thyroperoxidase Inhibition
Thyroxine (T4) in neuronal tissue Decreased
Tissue resident cell activation
Treat carbamazepine
Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsivenessCough Dyspnea
Trigeminal nerve activation
TRPA1 activation TRPA1 Receptor
Tumorigenesis Hepatocellular carcinoma
Uncoupling of oxidative phosphorylation Reduced ability to generate ATP
Under carboxylated clotting factors will not assemble on cell surfaces to form clot Failure of secondary hemostasis
Unfolded Protein Response
Up Regulation Acetyl-CoA carboxylase-1 (ACC-1)
Up Regulation CD36
Up Regulation CYP1A1
Up Regulation FAS
Up Regulation LDLR (low density lipoprotein receptor)
Up Regulation SCD-1
Up Regulation SREBF2
Up Regulation Unsaturated fatty acid
Upregulated Spindle assembly checkpoint protein Mad2-oocyte
Uroporphyria
Weak collagen matrix
Weakened Colony
Wnt ligand stimulation
β-catenin activation
All Chemicals
2,4-dichlorophenoxyacetic acid
acrinathrin
allethrin
alphacypermethrin
alphamethrin
bifenthrin
chlorpyrifos
cyfluthrin
cypermethrin
cyphenothrin
d-allethrin
d-phenothrin
d-tetramethrin
deltamethrin
dimethoate
empenthrin
epsilon-momfluorothrin
esbiothrin
esfenvalerate
etofenprox
fenpropathrin
fenvalerate
fipronil
gamma-cyhalothrin
glyphosate
imiprothrin
lambda-cyhalothrin
metofluthrin
permethrin
piperonyl butoxide
polyethoxylated-tallow-amine
prallethrin
tau-fluvalinate
tefluthrin
tetramethrin
transfluthrin
zeta-cypermethrin
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FUNDING: This work has been supported by
The HBM4EU project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 733032.
The HBM4EU project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 733032.