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Accueil > Equipes de recherche > Nano Bio spectroscopy > Thèmes de recherche

Research Activities

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Design of innovative nanoscale hybrid materials.

Our objective is to develop state-of-the-art technologies that will enable the elaboration of innovative hybrid nanomaterials for nanosensing devices and theranostic systems. We concentrate on the synthesis of magnetic (ferric oxide) and plasmonic (gold, silver) nanoparticles using bottom-up and top-down approaches (from soft chemical synthesis to lithography), in collaboration with ITODYS Laboratory. We also develop original strategies for the functionalization of nanoparticles, based on diazonium salt chemistry and controlled radical polymerization (ATRP, Iniferter).

Advanced nanotechnology for drug delivery, diagnostic and theranostic.

We develop an integrated strategy, from the design of innovative multifunctional nanoparticles to the study of their properties and their use as prognosis, diagnostic or therapeutic tools. Biomolecules such as antibodies, proteins, DNA or RNA are attached to the nanoparticles to obtain ultrasensitive nanosensors as early diagnostic tools for liquid biopsies (blood, urine, serum, synovial liquid). Key experiments include plasmon-assisted spectroscopies such as Surface-Enhanced Raman scattering (SERS), in collaboration with ITODYS Laboratory (N. Felidj). Various types of biomarkers are detected in biofluids, in close collaboration with biologists and medical doctors, including biomarkers from cartilage and surrounding joint tissue for rheumatology (in collaboration with F. Etienne, D. Borderie and C. Nguyen from UMR-S 1124 INSERM, University Paris Descartes). Metallic or oxide nanoparticles able to deliver drugs, heat or light to specific types of cells (such as cancer cells) are engineered to selectively target diseased cells or tissues.

Imaging and probe design.

We develop nanoscale contrast agents for various optical imaging techniques, such as Raman and photoacoustic imaging, in order to enhance contrast in the NIR region, where tissue optical absorption is minimized. The remarkable capacity of gold nanoparticles to absorb and scatter light at visible and near-infrared (NIR) regions are essential for optical imaging. In addition, these nanoparticles are able to convert optical energy into heat via nonradiative electron relaxation dynamics, which will endow them with intense photothermal properties for thermal therapy. We particularly focus on optimizing their absorption and photothermal properties, and we provide them ‘smart’ features, using pH-responsive coatings. Multifunctional nanoplatforms are being developed, with receptor targeting, multimodality imaging, and therapeutic entities for theranostic applications (collaboration with F. Gazeau).

Translating synovial fluid biomarkers to diagnostics using spectroscopy.

Early diagnosis is a key factor in the prevention and management of joint diseases. We aim to bring together the expertise of the Biospectroscopy team and medical doctors from Cochin Hospital (APHP) to meet this challenge and implement new diagnostic tools for joint diseases, using Surface-Enhanced Raman Spectroscopy. The primary goal is to analyze synovial fluids collected from patients by medical collaborators. We attempt to describe the biochemical and chemical changes undergone by synovial fluids in diseased joint tissues, such as alterations in protein composition and metabolomic profile. The involvement of medical doctors will boost the shift from basic research towards clinical applications to improve diagnosis, treatment and follow-up of rhumatology diseases.