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Accueil > Equipes de recherche > Synthèse Organique pour la Recherche Biomédicale > Publications

Publications

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2017
"Effect of uridine protecting groups on the diastereoselectivity of uridine-derived aldehyde 5'-alkynylation."
Ben Othman, R. ; Fer, M. J. ; Le Corre, L. ; Calvet-Vitale, S.* ; Christine Gravier-Pelletier, C.*
Beilstein J. Org. Chem. 2017, 13, 1533-1541.
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"Synthesis and biological evaluation of chemical tools for the study of Dolichol Linked Oligosaccharide Diphosphatase (DLODP)."
M. Bosco, M.; Massarweh, A. ; Iatmanen-Harbi, S.; Bouhss, A. ; Chantret, I.; Busca, P.; Moore, S. ; Gravier-Pelletier, C.*
Eur. J. Med. Chem. 2017, 125, 952-964
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2016

Synthesis of multi-functionalized 2-iminothiazolidin-4-ones and their 2-arylimino derivatives."
L. Le Corre, L. ; Dasso Lang, M. C. ; Garbay, C. ; Gravier-Pelletier, C. ; Busca, P. ; Ethève-Quelquejeu, M. ; Braud, E.*
Synthesis . 2016, 48, 4569-4579.
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"Brefeldin A promotes the appearance of oligosaccharyl phosphates derived from Glc3Man9GlcNAc2-PP-dolichol within the endomembrane system of HepG2 cells"
Massarweh, A.; Bosco, M.; Iatmanen-Harbi, S.; Tessier, C.; Amana, L.; Busca, P.; Chantret, I.; Gravier-Pelletier, C.; Moore, S. E. H.*
J. Lipid Res. 2016, 57(8), 1477-1491.
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"Demonstration of an oligosaccharide-diphosphodolichol diphosphatase activity whose subcellular localization is different than those of dolichyl-phosphate-dependent enzymes of the dolichol cycle"
Massarweh, A. ; Bosco, M. ; Iatmanen-Harbi, S. ; Tessier, C. ; Auberger, N. ; Busca, P. ; Chantret, I. ; Gravier-Pelletier, C. ; Moore, S. E. H.*
J. Lipid Res. 2016, 57(6), 1029-1042
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"Nucleophilic opening of an epoxide by a masked glycine anion equivalent : a route to C-glycosyl amino acids."
Fer, M. J. ; Bouhss, A. ; Patrão, M. ; Le Corre, L. ; Pietrancosta, N. ; Amoroso, A. ; M. Gayral, M.; Frlan, R.; Mravljak, J. Gravier-Pelletier, C.*
Synlett 2016, 27, 1551 - 1556
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"Synthesis of Six- and Seven-Membered Chloromethyl-Substituted Heterocycles via Palladium-Catalyzed Amino- and Oxychlorination"
Manick, A.-D.; Berhal, F.; Prestat, G.
Synthesis 2016, asap. en savoir plus

2015

"5′-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modelling"
Fer, M. J. ; Bouhss, A. ; Patrão, M. ; Le Corre, L. ; Pietrancosta, N. ; Amoroso, A. ; Joris, B. Mengin-Lecreulx, D. ; Calvet-Vitale, S.* ; Christine Gravier-Pelletier, C.*
Org. Biomol. Chem. 2015, 13, 7193-7222.
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"Copper(I)/Copper(II)-Assisted Tandem Catalysis: The Case Study of Ullmann/Chan-Evans-Lam N1,N3-Diarylation of 3-Aminopyrazole"
Beyer, A.; Castanheiro, T.; Busca, P.*; Prestat, G.*
ChemCatChem 2015, 7 (16), 2433-2436.
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"Molecular modeling study of the induced-fit effect on kinase inhibition: the case of fibroblast growth factor receptor 3 (FGFR3)"
Li, Y.; Delamar, M.; Busca, P.; Prestat, G.; Le Corre, L.; Legeai-Mallet, L.; Hu, R.; Zhang, R.; Barbault, F.*
Comput. Aided Mol. Des. 2015}, 29 (7), 619-641.
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2014

"A Diastereoselective Synthesis of 5′-Substituted-Uridine Derivatives"
Fer, M. J.; Doan, P.; Prangé, T.; Calvet-Vitale, S.* ; Gravier-Pelletier, C.*
J. Org. Chem. 2014, 79, 7758-7765.
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"Microwave-assisted preparation of 4-amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as building blocks for the diversity-oriented synthesis of pyrazole-based polycyclic scaffolds"
Le Corre, L.; Tak-Tak, L.; Guillard, A.; Prestat, G.; Gravier-Pelletier, C.; Busca, P.*
Org. Biomol. Chem. 2014, 13 (2), 409-423.
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"Synthesis of γ-Lactams and γ-Lactones via Pd-Catalyzed Allylations"
Kammerer, C.; Prestat, G.; Madec, D.; Poli, G.
Acc. Chem. Res. 2014, 47, 3439-3447.

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"Molecular modeling study of the induced-fit effect on kinase inhibition: the case of fibroblast growth factor receptor 3 (FGFR3)"
Li, Y.; Delamar, M.; Busca, P.; Prestat, G.; Le Corre, L.; Legeai-Mallet, L.; Hu, R.; Zhang, R.; Barbault, F.*
Comput. Aided Mol. Des. 2015, 29 (7), 619-641.
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2013

"Toward Analogues of MraY Natural Inhibitors: Synthesis of 5′-Triazole-Substituted-Aminoribosyl Uridines Through a Cu-Catalyzed Azide-Alkyne Cycloaddition"
Fer M.J.; Olatunji, S.; Bouhss, A.; Calvet-Vitale, S.*; Gravier-Pelletier, C.*
J. Org. Chem. 2013, 78, 10088-10105.
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"Antagonist of the fibroblast growth factor receptor 3 (fgfr3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of fgfr3"
Busca, P.; Barbault, F; Legeai-Mallet, L.
PATENT WO 2013088191 A1 20130620.
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2012

"A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model"
Jonquoy, A.; Mugniery, E.; Benoist-Lasselin, C.; Kaci, N.; Le Corre, L.; Barbault, F.; Girard, A.-L.; Merrer, Y. L.; Busca, P.; Schibler, L.; Munnich, A.; Legeai-Mallet, L.*
Hum. Mol. Genet. 2012, 21 (4), 841-851.
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2011

" Synthesis and biological evaluation of potential new inhibitors of the bacterial transferase MraY with a beta-ketophosphonate structure."
N. Auberger, R. Frlan, B. Al-Dabbagh, A. Bouhss, M. Crouvoisier, C. Gravier-Pelletier,* Y. Le Merrer.*
Org. Biomol. Chem. 2011, 9, 8301-8312.
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" Synthesis and biological evaluation of a diazepanone-based library of liposidomycins analogs as MraY inhibitors."
J. Mravljak, O. Monasson, B. Al-Dabbagh, M. Crouvoisier, A. Bouhss, C. Gravier-Pelletier,* Y. Le Merrer.*
Eur. J. Med. Chem. 2011, 1582-1592.
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"Synthesis of purin-2-yl and purin-6-yl-aminoglucitols as C-nucleosidic ATP mimics and biological evaluation as FGFR3 inhibitors"
Tak-Tak, L.; Barbault, F.; Maurel, F.; Busca, P.*; Le Merrer, Y.*
Eur. J. Med. Chem. 2011, 46 (4), 1254-1262.
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2010

" Bacterial transferase MraY inhibitors: synthesis and biological evaluation."
D. Lecerclé, A. Clouet, B. Al-Dabbagh, M. Crouvoisier, A. Bouhss, C. Gravier-Pelletier, * Y. Le Merrer. *
Bioorg. Med. Chem. 2010, 18, 4560-4569.
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"Decoding the Logic of the tRNA Regiospecificity of Nonribosomal FemXWv Aminoacyl Transferase"
Fonvielle, M.; Chemama, M.; Lecerf, M.; Villet, R.; Busca, P.; Bouhss, A.; Ethève-Quelquejeu, M.*; Arthur, M.*
Angew.Chem. Int. Ed. 2010, 49 (30), 5115-5119.
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"Idiosyncratic features in tRNAs participating in bacterial cell wall synthesis"
Villet, R.; Fonvielle, M.; Busca, P.; Chemama, M.; Maillard, A. P.; Hugonnet, J.-E.; Dubost, L.; Marie, A.; Josseaume, N.; Mesnage, S.; Mayer, C.; Valéry, J.-M.; Ethève-Quelquejeu, M.*; Arthur, M.*
Nucl. Acids Res. 2007, 35 (20), 6870-6883.
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2009

" Synthetic studies towards diazepanone scaffolds."
O. Monasson, M. Ginisty, J. Mravljak, G. Bertho, C. Gravier-Pelletier,* Y. Le Merrer.*
Tetrahedron Asymmetry 2009, 20, 2320-2330.
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" Synthesis of a beta-ketophosphonate bioisostere of UDP-N-Acetylglucosamine."
N. Auberger, C. Gravier-Pelletier,* Y. Le Merrer.*
Eur. J. Org. Chem. 2009, 3323-3326.
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2008

" Synthesis of 1-C-linked diphosphate analogues of UDP-N-Ac-glucosamine and UDP-N-Ac muramic acid."
A. Babič, S. Gobec, C. Gravier-Pelletier, Y. Le Merrer, S. Pečar.*
Tetrahedron 2008, 64, 9093-9100.
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" Efficient synthesis of a bacterial translocase MraY inhibitor "
A. Clouet, C. Gravier-Pelletier,* B. Al-Dabbagh, A. Bouhss, Y. Le Merrer. *
Tetrahedron: Asymmetry 2008, 19, 397-400.
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2007

"Idiosyncratic features in tRNAs participating in bacterial cell wall synthesis"
Villet, R.; Fonvielle, M.; Busca, P.; Chemama, M.; Maillard, A. P.; Hugonnet, J.-E.; Dubost, L.; Marie, A.; Josseaume, N.; Mesnage, S.; Mayer, C.; Valéry, J.-M.; Ethève-Quelquejeu, M.*; Arthur, M.*
Nucl. Acids Res. 2007, 35 (20), 6870-6883.
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" Synthesis of scaffolds with glycomimetics structures."
C. Gravier-Pelletier,* Y. Le Merrer.*
Current Organic Synthesis 2007, 4, 477-498.
" Efficient synthesis of polyfunctionalised enantiopure diazepanone scaffolds."
O. Monasson, M. Ginisty, G. Bertho, C. Gravier-Pelletier,* Y. Le Merrer.*
Tetrahedron Lett. 2007, 48, 8149-8152.
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" Towards new MraY inhibitors: a serinyl template for uracil and 5-amino-5-deoxyribosyl scaffolding."
L. Le Corre, C. Gravier-Pelletier,* Y. Le Merrer.*
Eur. J. Org. Chem. 2007, 5386-5394.
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" Synthesis of bis-(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-L-serinyl phosphate, as a prodrug of mannose-1-phosphate."
A. Khaled, C. Gravier-Pelletier,* Y. Le Merrer.*
Tetrahedron: Asymmetry 2007, 18, 2121-2124.
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"Mono, di and tri-mannopyranosyl phosphates as mannose-1-phosphate prodrugs for potential CDG-Ia therapy."
R. Hardré, A. Khaled, A. Willemetz, T. Dupré, S. Moore, C. Gravier-Pelletier,* Y. Le Merrer.*
Bioorg. Med. Chem. Lett. 2007, 17, 152-155.
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" Mannosyl-1 phosphates, preparation method and therapeutic use, in particular against the CDG-Ia syndrome."
C. Gravier-Pelletier, R. Hardré, A. Khaled, Y. Le Merrer
PATENT WO 2007/096532 A1.
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2006

"Synthesis of C-nucleosidic ATP mimics as potential FGFR3 inhibitors"
Busca, P.; McCort, I.; Prangé, T.; Le Merrer, Y.*
Eur. J. Org. Chem. 2006, 10, 2403-2409.
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