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Accueil > Equipes de recherche > Chimie, Biologie, Modélisation et Immunologie pour la Thérapie > Publications récentes


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  • Allam A, Maigre L, Vergalli J, Dumont E, Cinquin B, Alves de Sousa R, Pajovic J, Pinet E, Smith N, Herbeuval JP, Réfrégiers M, Artaud I, Pagès JM. Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria. Sci Rep. 2017 Apr 20
  • Müller J, Harms M, Schubert A, Mayer B, Jansen S, Herbeuval JP, Michel D, Mertens T, Vapalahti O, Schmidt-Chanasit J, Münch J. Development of a high-throughput colorimetric Zika virus infection assay. Medical Microbiology and Immunology, 2017 Feb
  • Smith N, Pietrancosta N, Dutrieux J, Davidson S, Chaveau L, Cuttolo P, Dy M, Scott-Algara D, Manoury B, McCort I, Dutroux T, Bachelerie F, Schwartz O, Wack A, Nisole S, Herbeuval JP. Natural amines inhibit activation of human pDC through CXCR4 engagement. (2017). Nature Communications. 2017 Feb

  • Grandin C, Hourani ML, Janin YL, Dauzonne D, Munier-Lehmann H, Paturet A, Taborik F, Vabret A, Contamin H, Tangy F, Vidalain PO. Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors. Antiviral Res. 2016 Jan;125:58-62
  • Mirabelli C, Pelletier I, Téoulé F, Vidalain PO, Brisac C, Tangy F, Delpeyroux F, Blondel B. The CREB3-Herp signalling module limits the cytosolic calcium concentration increase and apoptosis induced by poliovirus. J Gen Virol. 2016 Sep;97(9):2194-200. doi: 10.1099/jgv.0.000544
  • Dhers, L; Pietrancosta, N; Ducassou, L; Ramassamy, B; Dairou, J; Jaouen, M; André F; Mansuy, D; Boucher, JL. Spectral and 3D model studies of the interaction of orphan human cytochrome P450 2U1 with substrates and ligands. Biochim Biophys Acta. 2016 in press doi: 10.1016/j.bbagen.2016.07.018
  • Borhis G, Burelout C, Chaoul N, Smith N, Goujard C, Meyer L, Paul S, Saoudin H, Hosmalin A, Gilbert C, Herbeuval JP, Richard Y. PDC and mDC differently contribute to B-cell-activating factor belonging to the tumor necrosis factor superfamily overexpression during primary HIV infection. AIDS. 2016 Jan
  • Saïdi H, Bras M, Formaglio P, Melki MT, Charbit B, Herbeuval JP, Gougeon ML. HMGB1 Is Involved in IFN-α and TRAIL by HIV-1-Exposed pDC: Impact of the Crosstalk with NK Cells. PLoS Pathog. 2016 Feb
  • Smith N, Vidalain PO, Nisole S, Herbeuval JP. An efficient method for gene silencing in human primary plasmacytoid dendritic cells: silencing of the TLR7/IRF-7 pathway as a proof of concept. Sci Rep. 2016 Jul

  • Fernandez J, Portilho DM, Danckaert A, Munier S, Becker A, Roux P, Zambo A, Shorte S, Jacob Y, Vidalain PO, Charneau P, Clavel F, Arhel NJ. Microtubule-Associated Proteins 1 (MAP1) Promote Human Immunodeficiency Virus Type I (HIV-1) Intracytoplasmic Routing to the Nucleus. J Biol Chem. 2015 Feb 20;290(8):4631-46
  • Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Gigliola Z, Noel A, Tangy F, Vidalain PO, Janin Y. Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH). J. Med. Chem. 2015 Jan 58(2):860-77
  • Grandin C, Lucas-Hourani M, Clavel M, Taborik F, Vabret A, Tangy F, Contamin H, Vidalain PO. Evidence for an Intranasal Immune Response to Human Respiratory Syncytial Virus Infection in Cynomolgus Macaques. J. Gen. Virol. 2015 Apr 96(Pt 4):782-92
  • Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL. Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH). J Med Chem. 2015 Jun 58(14):5579-98
  • Stapleford KA, Rozen-Gagnon K, Das PK, Saul S, Poirier EZ, Blanc H, Vidalain PO, Merits A, Vignuzzi M. Viral polymerase-helicase complexes regulate replication fidelity to overcome intracellular nucleotide depletion. J Virol. 2015 Nov;89(22):11233-44
  • Ducassou, L; Jonasson, G; Dhers, L; Pietrancosta, N; Ramassamy, B; Xu-Li, Y; Loriot, MA; Beaune, P; Bertho, G; Lombard, M; Mansuy, D; André, F; Boucher, JL. Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies. Biochim. Biophys. Acta 2015, 1850, 1426-1437
  • Dao P, Smith N, Tomkiewicz-Raulet C, Yen-Pon E, Camacho-Artacho M, Lietha D, Herbeuval JP, CoumoulX, Garbay C, Chen H. Design, synthesis, and evaluation of novel imidazotriazines as focal adhesion kinase inhibitors with antitumor activity, J Med Chem, Jan 2015
  • Iannazzo L, Laisné G, Fonvielle M, Braud E, Herbeuval JP, Arthur M, Etheve-Quelquejeu. Synthesis of 3'-fluoro-tRNA analogues for exploring non-ribosomal peptide synthesis in bacteria. Chembiochem. 2015 Feb
  • Dao P*, Smith N*, Scott-Algara D, Garbay C, Herbeuval JP*, Chen H*. Restoration of TRAIL-induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor. Cancer Letters, April 2015
  • Smith N, Etheve-Quelquejeu M, Herbeuval JP. Transformation of pDC into giant multinuclear cells by HIV-1, AIDS Res Hum Retroviruses, May 2015
  • Griesbeck M, Ziegler S, Laffont S, Smith N, Chauveau L, Tomezsko P, Sharei A, Kourjian G, Porichis F, Hart M, Palmer CD, Sirignano M, Beisel C, Hildebrandt H, Cénac C, Villani AC, Diefenbach TJ, Le Gall S, Schwartz O, Herbeuval JP, Autran B, Guéry JC, Chang JJ, Altfeld M. Sex Differences in pDC Levels of IRF5 Drive Higher IFN-α Production in Women. J Immunol. 2015 Dec

  • 27. Lucas-Hourani M, Munier-Lehmann H, Helynck O, Komarova A, Desprès P, Tangy F, Vidalain PO. High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses. JOVE. 2014 May 5;(87
  • 26. Fournier G, Chiang C, Munier S, Tomoiu A, Demeret C, Vidalain PO, Jacob Y, Naffakh N. Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing. PLoS Pathog. 2014 Jun 12;10(6):e1004164
  • 25. Mottet-Osman G, Miazza V, Vidalain PO, Roux L. Patchwork structure-function analysis of the Sendai virus matrix protein. Virology. 2014 Sep;464-465:330-40
  • 24. Dao P, Jarray R, Smith N, Lepelletier Y, Le Coq J, Lietha D, Hadj-Slimane R, Herbeuval JP, Garbay C, Raynaud F*, Chen H*. Inhibition of both focal adhesion kinase and fibroblast growth factor receptor 2 pathways induces anti-tumor and anti-angiogenic activities, Cancer Letters, June 2014
  • 23. Barblu L*, Smith N*, Durand S, Scott D, Delfraissy JF, Cimarelli A, Lambotte O*, Herbeuval JP*. Reduction of DR5 and apoptosis of CD4+ T cells in HIV controllers, Clin Immunol, Nov 2014
  • 22. Santarem M, Fonvielle M, Sakkas N, Herbeuval JP, Braud E, Arthur M, Etheve-Quelquejeu M. Synthesis of 3'-triazoyl-dinucleotides as precursors of stable Phe-tRNA analogues. Bioorg Med Chem Lett. 2014 Aug
  • 21. Smith N, Etheve-Quelquejeu M, Herbeuval JP. CD4 and TRAIL localization in HIV-stimulated pDC by three-dimensional microscopy, AIDS Res Hum Retroviruses, December 2014

  • Gandini M, Gras C, Azeredo EL, de Oliviera Pinto LM, S mith N, Despres P, da Cunha RV, de Souza LR, Kubelka CF, Herbeuval JP. Dengue virus activates membrane TRAIL relocalization and IFN-α production by human pDC in vitro and in vivo, Plos Negl Trop Dis, Jun 2013
  • Gras C, Smith N, Sengmanivong L, Gandini M, Kubelka CF, Herbeuval JP. TRAIL protein localization in T cells by 3D microscopy using 3D interactive surface plot: A new method to visualize plasma membrane, Journal of Immunol Meth, Jan 2013.
  • Lucas-Hourani M, Dauzonne D, Jorda P, Cousin G, Lupan A, Helynck O, Caignard G, Janvier G, André-Leroux G, Khiar S, Escriou N, Desprès P, Jacob Y, Munier-Lehmann H, Tangy F, Vidalain PO. Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth Through Innate Immunity. PLoS Pathog. 2013 Oct;9(10):e1003678.
  • Téoulé F, Brisac C, Pelletier I, Vidalain PO, Jégouic S, Mirabelli C, Bessaud M, Combelas N, Autret A, Tangy F, Delpeyroux F, Blondel B. The Golgi Protein ACBD3, an Interactor for Poliovirus Protein 3A, Modulates Poliovirus Replication. J Virol. 2013 Oct;87(20):11031-46
  • Chauveau E, Doceul V, Lara E, Breard E, Sailleau C, Vidalain PO, Meurs EF, Dabo S, Schwartz-Cornil I, Zientara S, Vitour D. NS3 of bluetongue virus interferes with the induction of type I interferon. J Virol, 2013, July;87(14):8241-6.
  • Judith D, Mostowy S, Bourai M, Gangneux N, Lelek M, Lucas-Hourani M, Cayet N, Jacob Y, Prévost MC, Pierre P, Tangy F, Zimmer C, Vidalain PO, Couderc T, Lecuit M. Species-specific impact of the autophagy machinery on Chikungunya virus infection. EMBO Rep, 2013, June 3;14(6):534-44.
  • Komarova AV, Combredet C, Sismeiro O, Dillies MA, Jagla B, Sanchez David RY, Vabret N, Coppee JY, Vidalain PO, Tangy F. Identification of RNA partners of viral proteins in infected cells. RNA Biol, 2013, April 1;10(6).
  • Bampi C, Grenet AS, Caignard G, Vidalain PO, Roux L. The cellular protein TIP47 restricts Respirovirus multiplication leading to decreased virus particle production. Virus Res, 2013, May 173(2):354-63.
  • Caignard G, Lucas-Hourani M, Dhondt KP, Labernardière JL, Petit T, Jacob Y, Horvat B, Tangy F, Vidalain PO. The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells. PLoS One, 2013, January 8(1):e53881.
  • Lucas-Hourani M, Lupan A, Desprès P, Thoret S, Pamlard O, Dubois J, Guillou C, Tangy F, Vidalain PO*, Munier-Lehmann H*. A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2. J Biomol Screen, 2013, February 18(2):172-9

  • Herbeuval JP, Smith N., Thèze J. Characteristics of plasmacytoid dendritic cell and CD4+ T cell in HIV elite controllers. Clin and Dev Immunol. Nov 2012.
  • Barblu L, Machmach K, Gras C, Delfraissy JF, Boufassa F, Leal M, Ruiz-Mateos E, Lambotte O, Herbeuval JP. lasmacytoid dendritic cells (pDCs) from HIV controllers produce interferon-α and differentiate into functional killer pDCs under HIV activation. J Infect Dis, 2012 Sept.
  • Gougeon ML and Herbeuval JP. IFN-α and TRAIL: a double edge sword in HIV-1 disease? Review: Experimental cell Research, 2012 July.
  • Machmach K, Leal M, Gras C, Viciana P, Genebat M, Franco E, Boufassa F, Lambotte O, Herbeuval JP* and Ruiz-Mateos E *. Plasmacytoid dendritic cells reduce HIV production in elite controllers. J Virol, 2012 Apr.
  • Barblu L and Herbeuval JP. Three-dimensional microscopy characterization of death receptor 5 expression by over-activated human primary CD4+ T cells and apoptosis. PloS One, 2012 Mar 6.
  • Moreira-Teixeira L, Resende M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Dy M, Cordeiro-da-Silva A, Leite-de-Moraes MC. Rapamycin combined with TGF-β converts human invariant NKT cells into suppressive Foxp3+ regulatory cells. J Immunol, 2012 Jan 15.
  • Aynaud MM, Suspène R, Vidalain PO, Mussil B, Guétard D, Tangy F, Wain-Hobson S, Vartanian JP. Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A. J Biol Chem, 2012, November 9;287(46):39182-92.
  • Neveu G, Cassonnet P, Vidalain PO, Rolloy C, Mendoza J, Jones L, Tangy F, Muller M, Demeret C, Tafforeau L, Lotteau V, Rabourdin-Combe C, Travé G, Dricot A, Hill DE, Vidal M, Favre M, Jacob Y. Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase. Methods, 2012, December 58(4):349-59.
  • Mesel-Lemoine M, Millet J, Vidalain PO, Law H, Vabret A, Lorin V, Escriou N, Albert ML, Nal B, Tangy F. A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes. J Virol, 2012, July 86(14):7577-87
  • Bouraï M, Lucas-Hourani M, Gad HH, Drosten C, Jacob Y, Tafforeau L, Cassonnet P, Jones LM, Judith D, Couderc T, Lecuit M, André P, Kümmerer BM, Lotteau V, Desprès P, Tangy F, Vidalain PO. Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component. J Virol, 2012, March 86(6):3121-34.