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Accueil > Equipes de recherche > Pharmacochimie des récepteurs et des transporteurs des α-aminoacides > Publications récentes

Publications

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2018
  • Hajasova, Z., Canestrelli, C., Acher, F., Noble F., Marie N.,
    Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist.
    Neuropharmacol. 2018, 131, 424-430.

  • Lebourgeois S., Vilpoux C., Acher F., Marie N., Noble F., Naassila M.
    Pharmacological activation of mGluR4 and mGluR7, by LSP2-9166, reduces ethanol consumption and relapse in rat.
    Neuropharmacol. 2018, in press, DOI: 10.1016/j.neuropharm.2018.01.031

  • Chelliah, S., Lemasson, I. A., Brabet, I., Oueslati, N., Karaman, B., Cabaye, A., Tora, A. S., Commare, B., Courtiol, T., Cesarini, S., McCort-Tranchepain, I., Rigault, D., Mony, L., Bessiron, T., McLean, H., Leroux, F. R., Colobert, F., Daniel, H. Goupil-Lamy, A., Bertrand, H.-O., Goudet, C., Pin, J.-P. and Acher, F. C.
    Increased potency and selectivity for group-III metabotropic glutamate receptor agonists binding at dual sites
    J. Med. Chem. 2018, in press, DOI:10.1021/acs.jmedchem.7b01438.


2017
  • Woźniak M, Gołembiowska K, Noworyta-Sokołowska K, Acher F, Cieślik P, Kusek M, Tokarski K, Pilc A, Wierońska JM.
    Neurochemical and behavioral studies on the 5-HT1A-dependent antipsychotic action of the mGlu4 receptor agonist LSP4-2022.
    Neuropharmacol. 2017, 115, 149-165.
    doi: 10.1016/j.neuropharm.2016.06.025.


2016

  • Zussy, C.; Gómez-Santacana, X.; Rovira, X.; De Bundel, D.; Ferrazzo, S.; Bosch, D.; Asede, D.; Malhaire, F.; Acher, F.; Giraldo, J.; Valjent, E.; Ehrlich, I.; Ferraguti, F.; Pin, J.-P.; Llebaria, A.; Goudet, C.
    Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4.
    Mol Psychiatry 2016, in press

  • Tassin V., Girard B., Chotte A., Fontanaud P., Rigault D., Kalinichev M., Perroy J., Acher F, Fagni L. and Bertaso F.
    Frontiers in neural circuits 2016, 31, article number 31.

  • Wozniak M., Wieronska J. M., Acher F., Marciniak M., Lason-Tyburkiewicz M., Gruca P., Papp M. and Pilc A.
    The Involvement of GABAB signaling in the Antipsychotic-like Action of the Novel Orthosteric Agonist of mGlu4 Receptor, LSP4-2022.
    Cur Neuropharmacol 2016, 14(5), 413-426


2015

  • Tora A. S., Rovira X., Dione I., Bertrand H.-O., Brabet I., De Koninck Y., Doyon N., Pin J.-P., Acher F. and Goudet C.
    Allosteric modulation of metabotropic glutamate receptors by chloride ions.
    FASEB J. 2015, 29(10), 4174-88

  • Podkowa K, Rzeźniczek S, Marciniak M, Acher F, Pilc A, Pałucha-Poniewiera A.
    A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action.
    Neuropharmacology. 2015, 97, 338-45

  • Acher F. and Goudet C.
    , Therapeutic potential of group III metabotropic glutamate receptor ligands in pain.
    Cur Op Pharmacol, 2015, 20, 64-72

  • Commare B., Rigault D., Lemasson I., Deschamps P., Tomas A., Roussel P., Brabet I., Goudet C., Pin JP., Leroux F.R., Colobert F. and Acher F.
    Determination of the absolute configuration of phosphinic analogues of glutamate
    Org. Biomol. Chem., 2015, 13, 1106


2014

  • Acher F. and Selvam C.
    Expeditious Synthesis of bis-(α-hydroxyalkyl)phosphinic Acid Using N-O-bis (trimethylsilyl)acetamide (BSA),
    Cur Org Chem 2014 [Epub ahead of print]

  • Blarre T., Bertrand H.O., Acher F.C., Kehoe
    J. Molecular determinants of agonist selectivity in invertebrate glutamate-gated chloride channels which likely explain the agonist selectivity of vertebrate glycine and GABA A1 receptors.
    PLOS ONE 2014, 9 (9), e108458

  • Sakrikar NJ, Field JR, Klar R, Mattmann ME, Gregory KJ, Zamorano R, Engers DW, Bollinger SR, Weaver CD, Days EL, Lewis LM, Utley TJ, Hurtado M, Rigault D, Acher FC, Walker AG, Melancon BJ, Wood MR, Lindsley CW, Conn PJ, Xiang Z, Hopkins CR, Niswender CM.
    Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.
    ACS Chem Neurosci. 2014, 5, 1221

  • Favre-Besse FC., Poirel O., Bersot T., Kim-Grellier E., Daumas S., El Mestikawy S., Acher F.C., Pietrancosta N.
    Design, synthesis and biological evaluation of small-azo-dyes as potent Vesicular Glutamate Transporters inhibitors.
    Eur J Med Chem. 2014, 78, 236-247

  • M. Cajina, M. Nattini, D. Song, G. Smagin, E. B. Jørgensen, G. Chandrasena, C. Bundgaard, D. B. Toft, X. Huang, F. Acher, and D. Doller,
    Qualification of LSP1-2111 as a brain penetrant group III metabotropic glutamate receptor orthosteric agonist
    ACS Med. Chem. Lett. 2014,5, 119-123


2013

  • Vilar B., Busserolles J., Ling B., Laffray S., Ulmann, L., Malhaire F., Chapuy E., Youssef Aissouni Y., Etienne M., Bourinet E., Acher F., Pin JP., Eschalier A., Goudet C.
    Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor,
    J. Neurosci. 2013, 33, 18951-18965

  • Picard S., Cueto-Diaz E-J., Genin E., Clermont G., Acher A., Ogden D. and Blanchard-Desce M.
    Tandem triad systems based on FRET for two-photon induced release of glutamate.
    Chem. Commun., 2013, 49(92), 10805-7

  • Acher, F. C.
    Variations on glutamate binding in channel-gated receptors.
    Structure 2013, 21, (3) 317-319

  • Wierońska, J. M.; Acher, F. C.; Sławińska A; Gruca, P.; Łasoń-Tyburkiewicz, M.; Papp, M.; Pilc, A.
    The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT1A signalling.
    Psychopharmacology, 2013, 227 (4), 711-725.

  • Petit M., Tran, C., Roger, T., Gallavardin T., Dhimane H., Palma-Cerda F., Blanchard-Desce M., Acher F. C., Ogden D., Dalko P. I.
    Substitution effect on the one and two-photon sensitivity of DMAQ ‘caging' groups.
    Org Lett 2012, 14, 6366-6369.

  • Laras, Y.; Hugues, V.; Chandrasekaran, Y.; Blanchard-Desce, M.; Acher, F. C.; Pietrancosta, N.
    Synthesis of quinoline dicarboxylic esters as biocompatible fluorescent tags.
    J Org Chem. 2012, 77, 8294-8302.

  • M. J. Davis, O. D. Iancu, F. Acher, B. M. Stewart, M. A. Eiwaz, R. M. Duvoisin, J. Raber
    Role of mGluR4 in acquisition of fear learning and memory.
    Neuropharmacology 2013, 66, 365-372.

  • M. Amalric, S. Lopez, C. Goudet, G. Fisone, G. Battaglia, F. Nicoletti, J.-P. Pin, F. C. Acher
    Group III and Subtype 4 metabotropic glutamate receptor agonists: discovery and pathophysiological applications in Parkinson's disease.
    Neuropharmacology 2013 , 66, 53-64.


2012

  • P.J. Flor and F. C. Acher
    Orthosteric versus allosteric GPCR activation: The great challenge of group-III mGluRs.
    Biochem. Pharmacol. 2012, 84, 414-424.

  • M. Maurs, F. Acher, R. Azerad
    Microbial enantioselective removal of the N-benzyloxycarbonyl amino protecting group
    J Mol Cat B. 2012, 84, 22-26.

  • N. Pietrancosta, C. Anne, H. Prescher, R. Ruivo, C. Sagné, C. Debacker, H.-O. Bertrand, R. Brossmer, F. Acher and B. Gasnier.
    Successful prediction of the substrate-binding pocket in the SLC17 transporter sialin.
    J. Biol. Chem. 2012, 287, 11489-11497.

  • F. Fazio, L. Lionetto, G. Molinaro, H.O. Bertrand, F. Acher, R.T. Ngomba, S. Notartomaso, M. Curini, O. Rosati, P. Scarselli, R. Di Marco, G. Battaglia, V. Bruno, M. Simmaco, J. P. Pin, F. Nicoletti, and C. Goudet
    Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors
    Mol Pharmacol. 2012, 81, 643-656. (front cover illustration of May 2012 issue)

  • C. Goudet, B. Vilar, T. Courtiol, T. Deltheil, T. Bessiron, I. Brabet, N. Oueslati, D. Rigault, H.-O. Bertrand, H. McLean, H. Daniel, M. Amalric, F. Acher* and J.-P. Pin.
    A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.
    FASEB J. 2012, 26, 1682-1693.

  • Dubois, L.; Acher, F.; McCort, I.
    Microwave-promoted Michael addition of azaheterocycles to alpha,beta unsaturated esters and acid under solvent-free conditions.
    Synlett 2012, 220, 481-494.

  • Acher, F. C.
    Molecular Pharmacology of Metabotropic Glutamate Receptors.
    Tocris Bioscience Reviews 2011, http://www.tocris.com/scientificReviews.php

  • S. Lopez, A. Bonito-Oliva, S. Pallottino, F. Acher and G. Fisone.
    Activation of metabotropic glutamate 4 receptors decreases L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease.
    Journal of Parkinson's Disease 2011, 1, 339-346.

  • Wieronska, J.; Stachowicz, K.; Acher, F.; Lech, T.; Pilc, A.
    Opposite efficacy of group III mGlu receptors activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia.
    Psychopharmacology 2012, 220, 481-494.


2011

  • Acher, F. C.; Selvam, C.; Pin, J.-P.; Goudet, C.; Bertrand, H.-O.
    A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design.
    Neuropharmacology 2011, 60, 102-107.


2010

  • Wierońska JM, Stachowicz K, Pałucha-Poniewiera A, Acher F, Brański P, Pilc A.
    Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems.
    Neuropharmacology 2010, 59,627-634.

  • Mony, L.; Triballeau, N.; Paoletti, P.; Acher, F. C.; Bertrand, H.-O.
    Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach.
    Bioorg. Med. Chem. Lett. 2010, 20, 5552-5558.

  • Pietrancosta, N.; Kessler, A.; Favre-Besse, F-C.; Triballeau, N.; Quentin, T.; Giros, B.; El Mestikawy, S.; Acher, F. C.
    Rose Bengal analogs and Vesicular Glutamate Transporters (VGLUTs)
    Bioorg. Med. Chem. 2010, 18, 6922-6933.

  • Selvam, C.; Oueslati, N; Lemasson, I. A.; Brabet, I.; Rigault, D.; Courtiol, T.; Cesarini, S.; Triballeau, N.; Bertrand, H.-O.; Goudet, C.; Pin, JP.; Acher, F.C. A
    virtual screening hit reveals new possibilities to develop group III metabotropic glutamate receptor agonists
    J.Med.Chem. 2010, 53, 2797-2813.


2009
  • Kehoe, J.; Buldakova, S.; Acher F.; Dent, J.; Bregestovski, P.; Bradley, J.
    Aplysia cys-loop glutamate-gated chloride channels reveal convergent evolution of ligand specificity.
    J Mol Evol. 2009, 69, 125-141.

  • Beurrier, C.; Lopez, S.; Révy, D.; Selvam, C.; Goudet, C., Lhérondel, M., Gubellini, P., Kerkerian-LeGoff, L., Acher, F., Pin, JP., Amalric, M.
    Electrophysiological and behavioral evidences that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.
    FASEB J. 2009, 3619-3628.

  • Cuomo, D., Martella, G., Barabino, E., Platania, P.;Vita, D., Madeo, G., Selvam, C., Goudet, C., Oueslati, N., Pin, JP., Acher, F., Pisani, A., Beurrier, C., Melon, C., Kerkerian-Le Goff, L, Gubellini, P.
    Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment.
    J.Neurochem. 2009, 109, 1096-1105.

  • Mony, L.; Krzaczkowski, L.; Léonetti, M.; Le Goff, A.; Alarcon, K.; Neyton, J.; Bertrand, H.-O.; Acher, F.; Paoletti, P.
    Structural basis of NR2B-selective antagonist recognition by NMDA receptors.
    Mol. Pharmacol. 2009, 75, 60-74.


2008
  • Triballeau, N.; Van Name, E.; Laslier, G.; Cai, D.; Paillard, G.; Sorensen, P. W.; Hoffmann, R.; Bertrand, H.-O.; Ngai, J.; Acher, F. C.
    High potency olfactory receptor agonists discovered by virtual high-throughput screening: molecular probes for receptor structure and olfactory function.
    Neuron, 2008, 60, 761-771.

  • Abitbol, K.; Acher, F.; Daniel, H.
    Depression of excitatory transmission at PF-PC synapse by group III metabotropic glutamate receptors is provided exclusively by mGluR4 in the rodent cerebellar cortex.
    J. Neurochem. 2008,105, 2069-2079.

  • Cottyn, B.; Acher, F.; Ramassamy, B.; Alvey, L.; Lepoivre, M.; Frapart, Y.; Stuehr, D.; Mansuy, D.; Boucher, J.; Vichard, D.
    Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile.
    Bioorg. Med. Chem. 2008, 16, 5962-5975.

  • Goudet, C.; Chapuy, E.; Alloui, A.; Acher, A.; Pin, J.-P.; Eschalier, A.
    Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain.
    Pain 2008, 137, 112-124.


2007

  • Selvam, C.; Goudet, C.; Oueslati, N.; Pin, J.-P.; Acher, F.
    L(+)-2-amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.
    J.Med.Chem. 2007, 50, 4656-4664.

  • Lopez, S.; Turle-Lorenzo, N.; Acher, F.; De Leonibus, E.; Mele, A.; Amalric, M.
    Targeting group III metabotropic glutamate receptors produces complex behavioural effects in rodent models of Parkinson's disease.
    J. Neurosci. 2007, 27, 6701-6711.

  • Sibille, P.; Lopez, S.; Brabet, I.; Valenti, O.; Oueslati, N.; Gaven, F.; Goudet, C.; Bertrand, H.-O.; Neyton, J.; Marino, M. J.; Amalric, M.; Pin, J.-P.; Acher, F. C.
    Asymmetric synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropane carboxylic acids, new group III metabotropic glutamate receptor agonists.
    J. Med. Chem. 2007, 50 ,3585-3595.

  • Frauli, M.; Hubert, N.; Schann, S.; Triballeau, N.; Bertrand, H.-O.; Acher, F.; Neuville, P.; Pin, J.-P.; Prézeau
    , L. Amino-pyrrolidine tricarboxylic acids (APTCs) give new insight into group III metabotropic glutamate receptor activation mechanism.
    Mol. Pharmacol. 2007, 71, 704-712.


2006

  • Acher, F. C.
    Target validation: othogonal ligand-receptor pairs.
    in Comprehensive Medicinal Chemistry II vol3: Drug Discovery Technologies;
    Triggle, D. J., Taylor, J. B., Kubinyi, H. eds.; Elsevier: Oxford (U.K.), 2006; pp 215-234.

  • Schann, S.; Menet, C.; Arvault, P.; Mercier, G.; Frauli, M.; Mayer, S.; Hubert, N.; Triballeau, N.; Bertrand, H.-O.; Acher, F.; Neuville, P.
    Design and synthesis of APTCs (AminoPyrrolidine Tricarboxylic Acids): Identification of a new group III metabotropic glutamate receptor selective agonist.
    Bioorg. Med. Chem. Lett. 2006, 16, 4856-4860.


Till 2005

  • Triballeau, N.; Acher, F.; Brabet, I.; Pin, J.-P.; Bertrand, H.-O.
    Virtual screening workflow development guided by the ROC curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.
    J.Med.Chem. 2005, 48, 2534-2547.

  • Luu, P.; Acher, F.; Bertrand, H.-O.; Ngai, J.
    Odorant receptor specificities and receptor combinatorials: implications for olfactory coding.
    Chem Senses. 2005, 30 Suppl 1, i97-i98.

  • Goudet, C.; Kniazeff, J.; Hlavackova, V.; Malhaire, F.; Maurel, D.; Acher, F.; Blahos, J.; Prezeau, L.; Pin, J.-P.
    Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.
    J Biol Chem. 2005, 280, 24380-24385.

  • Conti, P.; De Amici, M.; Grazioso, G.; Roda, G.; Pinto, A.; Hansen, K. B.; Nielsen, B.; Madsen, U.; Brauner-Osborne, H.; Egebjerg, J.; Vestri, V.; Pellegrini-Giampietro, D. E.; Sibille, P.; Acher, F. C.; De Micheli, C.
    Synthesis, Binding Affinity at Glutamic Acid Receptors, Neuroprotective Effects, and Molecular Modeling Investigation of Novel Dihydroisoxazole Amino Acids.
    J. Med. Chem. 2005, 48, 6315-6325.

  • Acher, F.; Bertrand, H.-O.
    Amino acid recognition by Venus Flytrap domains is encoded in an 8 residue motif.
    Biopolymers 2005, 80, 357-366.

  • Pin, J.-P.; Kniazeff, J.; Goudet, C.; Bessis, A.-S.; Rondard, P.; Liu, J.; Acher, F. C.; Galvez, T.; Prézeau, L.
    The activation mechanism of class-III G-protein coupled receptors.
    Med Chem Res 2004, 13, 38-51.

  • Pin, J.-P.; Kniazeff, J.; Goudet, C.; Bessis, A.-S.; Liu, J.; Galvez, T.; Acher, F.; Rondard, P.; Prézeau, L.
    The activation mechanism of class-C G-protein coupled receptors.
    Biol. Cell 2004, 96, 335-342.

  • Luu, P.; Acher, F.; Bertrand, H.-O.; Fan, J.; Ngai, J.
    Molecular determinants of ligand selectivity in a vertebrate odorant receptor.
    J. Neurosci. 2004, 24, 10128-10137.

  • Goudet, C.; Gaven, F.; Kniazeff, J.; Vol, C.; Liu, J.; Cohen-Gonsaud, M.; Acher, F.; Prézeau, L.; Pin, J.-P.
    Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.
    Proc Nat Acad. Sci. USA 2004, 101, 378-383.

  • Binet, V.; Brajon, C.; Le Corre, L.; Acher, F.; Pin, J.-P.; Prézeau, L.
    The heptahelical domain of GABAB2 is directly activated by CGP7930,a positive allosteric modulator of the GABAB receptor.
    J. Biol. Chem. 2004, 279, 29085-29091.

  • Mutucumarana, V. P.; Acher, F.; Straight, D. L.; Jin, D. Y.; Stafford, D. W.
    A Conserved Region of Human Vitamin K-dependent Carboxylase between Residues 393 and 404 Is Important for Its Interaction with the Glutamate Substrate.
    J Biol Chem. 2003 2003, 278, 46488-44693.

  • Bessis, A.-S.; Vadesne, G.; Bourrat, E.; Bertho, G.; Pin, J.-P.; Acher, F.
    3-Carboxy-4-phosphonocyclopentane amino acids : new metabotropic glutamate receptor ligands.
    Amino Acids 2003, 24, 303-310.

  • Pin, J.-P.; Acher, F.
    The metabotropic glutamate receptors: structure, activation mechanism and pharmacology.
    Curr. Drug Targets - CNS & Neur. Dis. 2002, 1, 297-317.

  • Houben, R. J. T. J.; Rijkers, D. T. S.; Stanley, T. B.; Acher, F.; Azerad, R.; Käkönen, S. M.; Vermeer, C.; Soute, B. A. M.
    Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase binding domain on osteocalcin.
    Biochem. J. 2002, 364, 323.

  • Bessis, A.-S.; Rondard, P.; Gaven, F.; Brabet, I.; Triballeau, N.; Prézeau, L.; Acher, F.; Pin, J.-P.
    Closure of the Venus Flytrap module of mGlu8 receptor and the activation process: insights from mutations converting antagonists into agonists.
    Proc. Nat. Acad. Sci. USA 2002, 99, 11097-11102.

  • -Bertrand, H.-O.; Bessis, A.-S.; Pin, J.-P.; Acher, F.
    Common and selective molecular determinants involved in metabotropic glutamate receptor agonist activity.
    J. Med. Chem. 2002, 45, 3171-3183.

  • Bessis, A.-S.; Acher, F.; Pin, J.-P.
    Metabotropic glutamate receptors: exciting possibilities in excitatory transmission.
    Cell Transmission 2001, 17, 3-10.

  • Bessis, A.-S.; Bolte, J.; Pin, J.-P.; Acher, F.
    New probes of the agonist binding site of metabotropic glutamate receptors.
    Bioorg. Med. Chem. Lett. 2001, 11, 1569-1572.

  • Parmentier, M.-L.; Galvez, T.; Acher, F.; Peyre, B.; Pellicciari, R.; Grau, Y.; Bockaert, J.; Pin, J.-P.
    Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution.
    Neuropharmacology 2000, 39, 1119-1131.

  • De Colle, C.; Bessis, A.-S.; Bockaert, J.; Acher, F.; Pin, J.-P.
    Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor.
    Eur. J. Pharmacol. 2000, 394, 17-26.

  • Dauban, P.; de Saint-Fuscien, C.; Acher, F.; Prézeau, L.; Brabet, I.; Pin, J.-P.; Dodd, R. H.
    First enantiospecific synthesis of a 3,4-dihydroxy-L-Glutamic acid, a new mGluR1 agonist.
    Bioorg. Med. Chem. Lett. 2000, 10, 129-133.

  • Chesnoy-Marchais, D.; Lévi, S.; Acher, F.
    Glycinergic potentiation by some 5-HT3 antagonists: insight into selectivity.
    Eur. J. Pharmacol. 2000, 402, 205-213.

  • Bessis, A.-S.; Bertrand, H.-O.; Galvez, T.; De Colle, C.; Pin, J.-P.; Acher, F.
    Three-dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: new insights into the activation process.
    Protein Sci. 2000, 9, 2200-2209.

  • Jullian, N.; Brabet, I.; Pin, J.-P.; Acher, F.
    Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors : a different environment but similar recognition of an extended glutamate conformation. J.
    Med. Chem. 1999, 42, 1546-1555.

  • Bessis, A.-S.; Jullian, N.; Coudert, E.; Pin, J.-P.; Acher, F.
    Extended glutamate activates metabotropic receptor types 1, 2 and 4: selective features at mGluR4 binding site.
    Neuropharmacology 1999, 38, 1543-1551.

  • Tellier, F.; Acher, F.; Brabet, I.; Pin, J.-P.; Azerad, R.
    Aminobicyclo[2.2.1]heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and Glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2.
    Bioorg. Med. Chem. 1998, 6, 195-208.

  • Brabet, I.; Parmentier, M.-L.; Bockaert, J.; Acher, F.; Pin, J.-P.
    Effect of -carboxy-L-glutamate and DCG-IV on metabotropic glutamate receptor types 1, 2 and 4.
    Neuropharmacology 1998, 37, 1043-1051.

  • Acher, F.; Tellier, F.; Brabet, I.; Fagni, L.; Azerad, R.; Pin, J.-P.
    Synthesis and pharmacological characterization of aminocyclopentane tricarboxylic acids (ACPT): new tools to discriminate between metabotropic glutamate receptor subtypes.
    J. Med. Chem. 1997, 40, 3119-3129.

  • Tellier, F.; Acher, F.; Brabet, I.; Pin, J. P.; Bockaert, J.; Azerad, R.
    Synthesis of conformationally-constrained stereospecific analogs of glutamic acid as antagonists of metabotropic receptors.
    Bioorg. Med. Chem. Lett. 1995, 5, 2627-2632.