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Accueil > Equipes de recherche > Chimie Bio-inorganique des Dérivés Soufrés et Pharmacochimie > Publications récentes

Publication récentes

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2018

Larigot L, Juricek L, Dairou J, Coumoul X.
AhR signaling pathways and regulatory functions
Biochim Open. (2018 ) doi: 10.1016/j.biopen.2018.05.001.

Laurans L, Venteclef N, Haddad Y, Chajadine M, Alzaid F, Metghalchi S, Sovran B, Denis RGP, Dairou J, Cardellini M, Moreno-Navarrete JM, Straub M, Jegou S, McQuitty C, Viel T, Esposito B, Tavitian B, Callebert J, Luquet SH, Federici M, Fernandez-Real JM, Burcelin R, Launay JM, Tedgui A, Mallat Z, Sokol H, Taleb S.
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Nat Med. (2018 ) doi: 10.1038/s41591-018-0060-4.

Richarme G, , Abdallah J, Mathas N, Gautier V, Dairou J.
Further characterization of the Maillard deglycase DJ-1 and its prokaryotic homologs, deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL
Biochem Biophys Res Commun. (2018 ) . pii: S0006-291X(18)31376-7 (doi: 10.1016/j.bbrc.2018.06.064.)

Martin Dulac, Amor Sassi, Citra Nagarathinan, Marie-Odile Christen, Patrick M Dansette, Daniel Mansuy and Jean-Luc Boucher
Metabolism of anethole dithiolethione by rat and human liver microsomes: formation of various products deriving from its O-demethylation and S-oxidation. Involvement of cytochromes P450 and flavin monooxygenases in these pathways.
Drug Metab. Disp. (2018 ) DOI: https://doi.org/10.1124/dmd.118.082545

Pierre Lafite, François André, Joan P. Graves, Darryl C. Zeldin, Patrick M. Dansette and Daniel Mansuy
Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.
Int. J. Mol. Sci. (2018 ) 19, 2066.

Galardon E, Lec JC
Synthesis, characterization and reactivity of 3‐mercaptopyruvic acid.
Chembiochem (2018 ) https://doi.org/10.1002/cbic.201800199.

Neumann, F.; Gourdain, S.; Albac, C.; Dekker, A. D.; Bui, L. C.; Dairou, J.; Schmitz-Afonso, I.; Hue, N.; Rodrigues-Lima, F.; Delabar, J. M.; Potier, M. C.; Le Caer, J. P.; Touboul, D.; Delatour, B.; Cariou, K.; Dodd, R. H..
DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives.
Sci Rep (2018 ) 8 (1), 2859.

Metghalchi, S.; Vandestienne, M.; Haddad, Y.; Esposito, B.; Dairou, J.; Tedgui, A.; Mallat, Z.; Potteaux, S.; Taleb, S.
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.
PLoS One (2018 ) 55 (5), 13 (3), e0193737.

Machover, D.; Goldschmidt, E. L.; Mollicone, R.; Haghighi-Rad, F.; Desterke, C.; Gaston-Mathe, Y.; Saffroy, R.; Boucheix, C.; Dairou, J.
Enhancement of 5-Fluorouracil cytotoxicity by Pyridoxal 5'-phosphate and Folinic acid in tandem.
J Pharmacol Exp Ther (2018 ) 55 (5), 3822-3831..

London, J.; Rouch, C.; Bui, L. C.; Assayag, E.; Souchet, B.; Daubigney, F.; Medjaoui, H.; Luquet, S.; Magnan, C.; Delabar, J. M.; Dairou, J.; Janel, N.,
Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues.
Mol Metab (2018 ) 8, 23-36.

Campana, M.; Bellini, L.; Rouch, C.; Rachdi, L.; Coant, N.; Butin, N.; Bandet, C. L.; Philippe, E.; Meneyrol, K.; Kassis, N.; Dairou, J.; Hajduch, E.; Colsch, B.; Magnan, C.; Le Stunff, H
Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances beta-cell function of obese Zucker rats.
Chembiochem (2018 ) Mol Metab 2018, 8, 23-36.

Durand CM, Dhers L, Tesson C, Tessa A, Fouillen L, Jacqueré S, Raymond L, Coupry I, Benard G, Darios F, El-Hachimi KH, Astrea G, Rivier F, Banneau G, Pujol C, Lacombe D, Durr A, Babin PJ, Santorelli FM, Pietrancosta N, Boucher JL, Mansuy D, Stevanin G, Goizet C.CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56.
Hum Mutat (2018) 39(1):140-151.

Yong Wang, Patrick M. Dansette, Pascal Pigeon, Siden Top, Michael J. McGlinchey, Daniel Mansuy and Gérard Jaouen
A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties.
Chem. Sci. (2018) 9, 70-78 DOI: 10.1039/C7SC04213B.


2017

Lamrani M, Sassi N, Paul C, Yousfi N, Boucher JL, Gauthier N, Labbé J, Seignez C, Racoeur C, Athias A, Guerreiro R, Vergely C, Rochette L, Bettaieb A, Jeannin JF.
TLR4/IFNγ pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models.
Oncoimmunology (2015 ) 29;5(5):e1123369.

Dhers L, Ducassou L, Boucher JL, Mansuy D
Cytochrome P450 2U1, a very peculiar member of the human P450s family.
Cell Mol Life Sci. (2017) 74(10):1859-1869.

Ducassou L, Dhers L, Jonasson G, Pietrancosta N, Boucher JL, Mansuy D, André F.
Membrane-bound human orphan cytochrome P450 2U1: Sequence singularities, construction of a full 3D model, and substrate docking.
Biochimie. (2017) 22;61(10). 140:166-175.

Durand CM, Dhers L, Tesson C, Tessa A, Fouillen L, Jacqueré S, Raymond L, Coupry I, Benard G, Darios F, El-Hachimi KH, Astrea G, Rivier F, Banneau G, Pujol C, Lacombe D, Durr A, Babin PJ, Santorelli FM, Pietrancosta N, Boucher JL, Mansuy D, Stevanin G, Goizet C.
CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56.
Hum Mutat (2018) 39(1):140-151.

Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso PV, Tangy F,Vidalain PO.
Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response.
Antimicrob Agents Chemother. (2017) 22;61(10). pii: e00383-17. doi: 10.1128/AAC.00383-17.

Campana M, Bellini L, Rouch C, Rachdi L, Coant N, Butin N, Bandet CL, Philippe E, Meneyrol K, Kassis N, Dairou J, Hajduch E, Colsch B, Magnan C, Le Stunff H.
Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats..
Mol Metab (2017) S2212-8778(17)30690-7. doi: 10.1016/j.molmet.2017.10.013.

Simon V, Avet C, Grange-Messent V, Wargnier R, Denoyelle C, Pierre A, Dairou J, Dupret JM, Cohen-Tannoudji J.
Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway.
Endocrinology (2017) 158(10):3200-3211. doi: 10.1210/en.2017-00374.

Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M.
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.
Mol Metab. (2017) 26;6(4):340-351. doi: 10.1016/j.molmet.2017.01.009.

Sodhi JK, Delarosa EM, Halladay JS, Driscoll JP, Mulder T, Dansette PM, Khojasteh SC.
Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms
Int J Mol Sci. (2017) Jul 20;18(7) doi: 10.3390/ijms18071553.

Boumaiza M, Chahed H, Ezzine A, Jaouen M M, Gianoncelli A, Longhi G, Carmona F, Arosio P, Sari MA* M, Marzouki MN.
Recombinant overexpression of camel hepcidin cDNA in Pichia pastoris: purification and characterization of the polyHis-tagged peptide HepcD-His.
J Mol Recognit (2017) . 2017doi: 10.1002/jmr.2561.

Allam A M, Maigre L, Alves de Sousa R M, Dumont E, Vergalli J, Pagès JM, Artaud I M.
New Amphiphilic Neamine Conjugates Bearing a Metal Binding Motif Active Against MDR E. aerogenes Gram-negative Bacteria.
Eur. J. Med. Chem. 2017, 127, 748-756

Allam A M, Maigre L, Vergalli J, Dumont E, Cinquin B, Alves de Sousa R M, Pinet E, Smith N M, Herbeuval JP M, Réfrégiers M, Artaud I M, Pagès JM.
Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria
Sci. Rep. (2017) (7) 986

Richarme G M, Dairou J. M
“Parkinsonism-associated protein DJ-1 is a bona fide deglycase.”
Biochem Biophys Res Commun. (2017) . 29;483(1):387-391. doi: 10.1016/j.bbrc.2016.12.134.

Mamadou G, Charrueau C, Dairou J , Limas Nzouzi N, Eto B, Ponchel G.
“Increased intestinal permeation and modulation of presystemic metabolism of resveratrol formulated into self-emulsifying drug delivery systems.”
Int J Pharm. (2017) 17;521(1-2):150-155. doi: 10.1016/j.ijpharm.2017.02.036.

Haddadi-Guemghar H, Tlili A, Dairou J , Paul JL, Madani K, Janel N.
"Effect of lyophilized prune extract on hyperhomocysteinemia in mice.”
Food Chem Toxicol. (2017) 10;103:183-187. doi: 10.1016/j.fct.2017.03.018.

Dhers L , Ducassou L , Boucher JL , Mansuy D.
Cytochrome P450 2U1, a very peculiar member of the human P450S family.
Cell Mol Life Sci. 2017. 74(10):1859-1869. doi: 10.1007/s00018-016-2443-3. REVIEW

Dhers L , Pietrancosta N, Ducassou L M, Ramassamy B , Dairou J , Jaouen M, André F, Mansuy D, Boucher JL.
Spectral and 3D model studies of the interaction of orphan human cytochrome P450 2U1 with substrates and ligands.
Biochim Biophys Acta. 2017 Jan;1861(1 Pt A):3144-3153. doi: 10.1016

Sarkis M, Miteva MA, Dasso Lang MC, Jaouen M, Sari MA, Galcéra MO, Ethève-Quelquejeu M, Garbay C, Bertho G, Braud E.
Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25.
Proteins. 2017 Apr;85(4):593-601. doi: 10.1002/prot.25236. Epub 2017 Jan 18.

Galardon E, Huguet F, Herrero C, Ricoux R, Artaud I, Padovani D
. Reactions of persulfides with the heme cofactor of oxidized myoglobin and microperoxidase 11: reduction or coordination.
Dalton Trans. 46(24):7939-7946.

Leverrier A, Hilf M, Raynaud F, Deschamps P, Roussel P, Tomas A, Galardon E.
Synthesis and anti-proliferative activities of ruthenium complexes containing the hydrogen sulfide-releasing ligand GYY4137.
J. Organomet. Chem 2017, (843), 26-31

Richarme G, Liu C, Mihoub M, Abdallah J, Leger T, Joly N, Liebart JC, Jurkunas U, Nadal M, Bouloc P, Dairou J, Lamouri A.
Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.
Science, accepted juin 2017

Padovani D
(2017)[A new link between high homocysteine levels, cancers and neurodegenerative diseases].

Med Sci (Paris) 33(5):494-497.Revue

London J, Rouch C, Bui LC, Assayag E, Souchet B, Daubigney F, Medjaoui H, Luquet S, Magnan C, Delabar JM, Dairou J, Janel N.
Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues.
Mol Neurobiol. 2017 May 25. doi: 10.1007/s12035-017-0591-6.


2016

Mathieu A, Fleurier S, Frénoy A, Dairou J, Bredeche MF, Sanchez-Vizuete P, Song X, Matic I.
Discovery and Function of a General Core Hormetic Stress Response in E. coli Induced by Sublethal Concentrations of Antibiotics.
Cell Rep. . 2016, Sep 27;17(1):46-57.(doi: 10.1016/j.celrep.2016.09.001)

Rouaud F, Boucher JL, Slama-Schwok A, Rocchi S.
CMechanism of melanoma cells selective apoptosis induced by a photoactive NADPH analogue
Oncotarget (2016) 7(50):82804-82819.

Fieulaine F., Alves de Sousa R., Maigre L., Hamiche K., Alimi M., Bolla J.-M., Taleb A., Denis A., Pagès J.-M., Artaud I., Meinnel T., Giglione C.
A unique peptide deformylase platform to rationally design and challenge novel active compounds.
Sci. Rep. . 2016, 6, 35429.

Allam A., Maigre L., Alves de Sousa R., Dumont E., Vergalli J., Pagès J.-M., Artaud I., Meinnel T., Giglione C
New Amphiphilic Neamine Conjugates Bearing a Metal Binding Motif Active Against MDR E. aerogenes Gram-negative Bacteria
Eur. J. Med. Chem. . 2016, in press (doi: 10.1016/j.ejmech.2016.10.054)

Sakanyan V., Benaiteau F., Alves de Sousa R., Pineau C., Artaud I.
Straightforward detection of reactive compound binding to multiple proteins in cancer cells: towards a better understanding of electrophilic stress.
Ann. Clin. Exp. Metabol. . 2016, 1(1), 1006

Padovani D., Hessani A., Castillo F. T., Liot G., Andriamihaja M., Lan A., Pilati C., Blachier F., Sen S., Galardon E. &Artaud I.
Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases
Nat. Commun. . 2016, 7:13386

Gomez I., Özen G., Deschildre C., Amgoud, Y., Boubaya L., Gorenne I, Benyahia C., Roger T., Lesèche G., Galardon E. , Topal G., Jacob, M.P., Longrois D., Norel X
Reverse regulatory pathway (H2S / PGE2 / MMP) in human aortic aneurysm and saphenous vein varicosity
PLoS One . 2016, 1(6):e0158421

Wang Y, Richard MA, Top S, Dansette PM, Pigeon P, Vessières A, Mansuy D, Jaouen G.
Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation.

Angew Chem Int Ed Engl. 2016 Jun 8. doi: 10.1002/anie.201603931.
Abou-Hamdan A, Ransy C, Roger T, Guedouari-Bounihi H, Galardon E, Bouillaud F.
Positive feedback during sulfide oxidation fine-tunes cellular affinity for oxygen.
Biochim Biophys Acta. 2016 Apr 29;1857(9):1464-1472.

Boualem A., Lemhemdi A., Sari M.A., Pignoly S., Troadec C., Abou Choucha F., Solmaz I., Sari N., Dogimont C., Bendahmane A.
Andromonoecious Sex Determination Gene Predates the Separation of Cucumis and Citrullus
PLoS One 2016 , in press, http://dx.doi.org/10.1371/journal.pone.0155444.

Sakanyan V, Hulin P, Alves de Sousa R, Silva VA, Hambardzumyan A, Nedellec S, Tomasoni C, Logé C, Pineau C, Roussakis C, Fleury F, Artaud I.
Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1
Sci Rep. 2016 Feb 17;6:21088. doi: 10.1038/srep21088

Brunel, A., Lang, J., Couture, M., Boucher, J.L., Dorlet, P., and Santolini, J.
Oxygen activation in NO synthases: evidence for a direct role of the substrate FEBS Open Bio 2016, 6, 386–397.

Wedmann R, Onderka C, Wei S, Szijártó IA, Miljkovic JL, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipovic M. Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation Chem. Sci. . 2016, May 25;7(5):3414-3426

Leonova, E., Sokolovska, J., Boucher, J.L., Isajevs, S., Rostoka, E., Baumane, L., Sjakste, T., Sjakste, N.
New 1,4-Dihydropyridines Down-regulate Nitric Oxide in Animals with Streptozotocin-induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action. Basic Clin Pharmacol Toxicol. 2016, 119, 19-31.


2015

Houamel D, Ducrot N, Lefebvre T, Daher R, Moulouel B, Sari MA, Letteron P, Lyoumi S, Millot S, Tourret J, Bouvet O, Vaulont S, Vandewalle A, Denamur E, Puy H, Beaumont C, Gouya L, Karim Z.
Hepcidin as a Major Component of RenalAntibacterial Defenses against Uropathogenic Escherichia coli.
J Am Soc Nephrol. 2015 Aug 20. pii: ASN.2014101035. PubMed PMID: 26293821

Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A.
Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues J. Biol. Chem. . 2015, 16;290(3):1885-97

Boualem A, Troadec C, Camps C, Lemhemdi A, Morin H, Sari MA, Fraenkel-Zagouri R, Kovalski I, Dogimont C, Perl-Treves R, Bendahmane A.
A cucurbit androecy gene reveals how unisexual flowers develop and dioecy emerges.
Science2015, 350(6261):688-91.

Lamrani M, Sassi N, Paul C, Yousfi N, Boucher JL, Gauthier N, Labbé J, Seignez C, Racoeur C, Athias A, Guerreiro R, Vergely C, Rochette L, Bettaieb A, Jeannin JF.
TLR4/IFNγ pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models.
Oncoimmunology (2015 ) 29;5(5):e1123369.

Duval R, Bui LC, Berthelet J, , Dairou J,, Mathieu C, Guidez F, Dupret JM, Cools J, Chomienne C, Rodrigues-Lima F
A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) Sci Rep. . 2015, 16 Jun 4;5:10750

Galardon, E.; Padovani, D.
Reactivity of Persulfides Towards Strained Bicyclo[6.1.0]nonyne Derivatives: Relevance to Chemical Tagging of Proteins.
Bioconj. Chem.2015, 26, 1013-1016

Mihoub M, Abdallah J, Gontero B, Dairou J, Richarme G.
The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal BiochemBiophys Res Commun. . 2015, Aug 7;463(4):1305-10

Chan Ho Tong L, Dairou J, Bui LC, Bouillon J, Rodrigues-Lima F, Dupret JM, Silar P.
Screen for soil fungi highly resistant to dichloroaniline uncovers mostly Fusarium species Fungal Genet Biol. . 2015, Aug;81:82-7

Gemble S, Ahuja A, Buhagiar-Labarchède G, Onclercq-Delic R, Dairou J,> Biard DS, Lambert S, Lopes M, Amor-Guéret M.
Pyrimidine Pool Disequilibrium Induced by a CytidineDeaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA PLoS Genet. . 2015, Jul 16;11(7):e1005384

Messaoudi N, Gautier V, Dairou J, Mihoub M, Lelandais G, Bouloc P, Landoulsi A, Richarme G
Fermentation and Alternative Respiration Compensate for NADH Dehydrogenase Deficiency in a Prokaryotic Model of DJ-1 Associated Parkinsonism Microbiology . 2015, 2. 15. doi: 10.1099/mic.0.000181.

Dansette PM, Levent D, Hessani A, Mansuy D.
Bioactivation of Clopidogrel and Prasugrel: Factors Determining the Stereochemistry of the Thiol Metabolite Double Bond
Chem.Res. Toxicol.2015, 28 (6), pp 1338-1345

Richard MA, Hamels D, Pigeon P, Top S, Dansette PM, Lee HZ, Vessières A, Mansuy D, Jaouen G.
Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.
ChemMedChem2015, 10(6):981-90

Ducassou L, Jonasson G, Dhers L, Pietrancosta N, Ramassamy B, Xu-Li Y, Loriot MA, Beaune P, Bertho G, Lombard M, Mansuy D, André F, Boucher JL.
Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies.
Biochim Biophys Acta2015, 1850(7):1426-37

Bluhm U, Boucher JL, Clement B, Girreser U, Heber D, Ramassamy, Wolschendorf U.
Synthesis, Characterization and NO Synthase Inhibition Testing of 2-Aryl-5-aroyl-3,4,5,6-tetrahydropyrimidinium Chlorides.
Heterocycles 2015 52: 24-39.

2014

Weisser, S. B.; Kozicky, L. K.; Brugger, H. K.; Ngoh, E. N.; Cheung, B.; Jen, R.; Menzies, S. C.; Samarakoon, A.; Murray, P. J.; Lim, C. J.; Johnson, P.; Boucher, J. L.; van Rooijen, N.; Sly, L. M.,
Arginase activity in alternatively activated macrophages protects PI3Kp110delta deficient mice from dextran sodium sulfate induced intestinal inflammation
Eur J Immunol2014. 44(11):3353-67

Rouaud F, Romero-Perez M, Wang H, Lobysheva I, Ramassamy B, Henry E, Tauc P, Giacchero D, Boucher JL, Deprez E, Rocchi S, Slama-Schwok A.
Oncotarget. (2014) 15;5(21):10650-64

Terzic, V.; Padovani, D.; Balland, V.; Artaud, I.; Galardon, E.,
Electrophilic sulfhydration of 8-nitro-cGMP involves sulfane sulfur
Org Biomol Chem2014, 12 (29), 5360-4.

Padovani, D.; Folly-Klan, M.; Labarde, A.; Boulakirba, S.; Campanacci, V.; Franco, M.; Zeghouf, M.; Cherfils, J.,
EFA6 controls Arf1 and Arf6 activation through a negative feedback loop
Proc Natl Acad Sci U S A2014, 111 (34), 12378-83.

Osborne, L. C.; Monticelli, L. A.; Nice, T. J.; Sutherland, T. E.; Siracusa, M. C.; Hepworth, M. R.; Tomov, V. T.; Kobuley, D.; Tran, S. V.; Bittinger, K.; Bailey, A. G.; Laughlin, A. L.; Boucher, J. L.; Wherry, E. J.; Bushman, F. D.; Allen, J. E.; Virgin, H. W.; Artis, D.,
Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation
Science2014, 345 (6196), 578-82.

Decroos, C.;Boucher, J. L.; Mansuy, D.; Xu-Li, Y.,
Reactions of amino acids, peptides, and proteins with oxidized metabolites of tris(p-carboxyltetrathiaaryl)methyl radical EPR probes
Chem Res Toxicol2014, 27 (4), 627-36.

Chen, F.; Wu, W.; Millman, A.; Craft, J. F.; Chen, E.; Patel, N.; Boucher, J. L.; Urban, J. F., Jr.; Kim, C. C.; Gause, W. C.,
Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion
Nat Immunol2014, 15 (10), 938-46.

Boumaiza, M.; Ezzine, A.; Jaouen, M.; Sari, M. A.; Marzouki, M. N.,
Molecular characterization of a novel hepcidin (HepcD) from Camelus dromedarius. Synthetic peptide forms exhibit antibacterial activity
J Pept Sci 2014, 20 (9), 680-688.

Borriello, L.; Montes, M.; Lepelletier, Y.; Leforban, B.; Liu, W. Q.; Demange, L.; Delhomme, B.; Pavoni, S.; Jarray, R.; Boucher, J. L.; Dufour, S.; Hermine, O.; Garbay, C.; Hadj-Slimane, R.; Raynaud, F.,
< i> Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model
Cancer Lett2014, 349 (2), 120-7.

Beziere, N.; Hardy, M.; Poulhes, F.; Karoui, H.; Tordo, P.; Ouari, O.; Frapart, Y. M.; Rockenbauer, A.; Boucher, J. L.;Mansuy, D.; Peyrot, F.,
Metabolic stability of superoxide adducts derived from newly developed cyclic nitrone spin traps
Free Radic Biol Med2014, 67, 150-8.

Artaud, I.;Galardon, E.,
A Persulfide Analogue of the Nitrosothiol SNAP: Formation, Characterization and Reactivity
Chembiochem 2014. 15(16):2361-4.

Allam, A.; Maigre, L.; Alimi, M.; Alves de Sousa, R.; Hessani, A.; Galardon, E.; Pages, J. M.; Artaud, I.,
New Peptides with Metal Binding Abilities and Their Use as Drug Carriers
Bioconjug Chem2014, 25(10):1811-9


2013

Roger, T.; Raynaud, F.; Bouillaud, F.; Ransy, C.; Simonet, S.; Crespo, C.; Bourguignon, M. P.; Villeneuve, N.; Vilaine, J. P.; Artaud, I.;Galardon, E.
New biologically active hydrogen sulfide donors
Chembiochem2013, 14 (17), 2268-71.

Pages, J. M.; Kascakova, S.; Maigre, L.; Allam, A.; Alimi, M.; Chevalier, J.; Galardon, E.; Refregiers, M.; Artaud, I.,
New Peptide-based antimicrobials for tackling drug resistance in bacteria: single-cell fluorescence imaging
Acs Med Chem Lett2013, 4 (6), 556-9.

Padovani, D.; Zeghouf, M.; Traverso, J. A.; Giglione, C.; Cherfils, J.,
High yield production of myristoylated Arf6 small GTPase by recombinant N-myristoyl transferase
Small GTPases2013, 4 (1), 3-8.

Mansuy, D.,
Metabolism of xenobiotics: beneficial and adverse effects
Biologie aujourd'hui2013, 207 (1), 33-7.

Lofgren, M.; Padovani, D.; Koutmos, M.; Banerjee, R.,
A switch III motif relays signaling between a B12 enzyme and its G-protein chaperone
Nat Chem Biol 2013, 9 (9), 535-9.

Huang, M. L. H.; Austin, C. J. D.; Sari, M. A.; Rahmanto, Y. S.; Ponka, P.; Vyoral, D.; Richardson, D. R.,
Hepcidin Bound to alpha(2)-Macroglobulin Reduces Ferroportin-1 Expression and Enhances Its Activity at Reducing Serum Iron Levels
Journal of BiologicalChemistry 2013, 288 (35), 25450-25465.

Galardon, E.;Daguet, H.; Deschamps, P.; Roussel, P.; Tomas, A.; Artaud, I.,
Influence of the diamine on the reactivity of thiosulfonato ruthenium complexes with hydrosulfide (HS-)
Dalton transactions 2013, 42 (8), 2817-21.

2012

Soler, N.; Craescu, C. T.;Gallay, J.; Frapart, Y. M.; Mansuy, D.; Raynal, B.; Baldacci, G.;Pastore, A.; Huang, M. E.; Vernis, L., A
S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2
FebsJ 2012, 279 (12), 2108-19.

Singh, K.; Coburn, L. A.; Barry, D. P.; Boucher, J. L.; Chaturvedi, R.; Wilson, K. T.,
L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution
Am J Physiol Gastrointest Liver Physiol2012, 302 (9), G1061-73.

Salard-Arnaud, I.; Stuehr, D.; Boucher, J. L.; Mansuy, D.,
Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases
J Inorg Biochem2012, 106 (1), 164-71.

Robles, V. M.; Marechal, J. D.; Bahloul, A.; Sari, M. A.; Mahy, J. P.; Golinelli-Pimpaneau, B.,
Crystal Structure of Two Anti-Porphyrin Antibodies with Peroxidase Activity
Plos One2012, 7 (12).

Messina, P.; Labbe, E.; Buriez, O.; Hillard, E. A.; Vessieres, A.; Hamels, D.; Top, S.; Jaouen, G.; Frapart, Y. M.; Mansuy, D.; Amatore, C.,
Deciphering the activation sequence of ferrociphenol anticancer drug candidates
Chemistry2012, 18 (21), 6581-7.

Li, Y.; Wang, H.; Tarus, B.; Perez, M. R.; Morellato, L.; Henry, E.; Berka, V.; Tsai, A. L.; Ramassamy, B.; Dhimane, H.; Dessy, C.; Tauc, P.; Boucher, J. L.; Deprez, E.; Slama-Schwok, A.,
Rational design of a fluorescent NADPH derivative imaging constitutive nitric-oxide synthases upon two-photon excitation
Proc Natl Acad Sci U S A2012, 109 (31), 12526-31.

Khemtemourian, L.; Desbenoit, N.; Mahesh, P.; Chatterjee, S.; Deschemin, J. C.; Vaulont, S.; Tomas, A.; Sari, M. A.; Artaud, I.,
Synthesis and Biological Activity of Mouse Hepcidin Peptide Analogs Containing Three Disulfide Bridges: Manual and Microwave-Assisted Solid-Phase Peptide Synthesis
Protein Peptide Lett2012, 19 (2), 219-227.

Huguet, F.; Melet, A.; Alves de Sousa, R.; Lieutaud, A.; Chevalier, J.; Maigre, L.; Deschamps, P.; Tomas, A.; Leulliot, N.; Pages, J. M.; Artaud, I.,
Hydroxamic acids as potent inhibitors of Fe(II) and Mn(II) E. coli methionine aminopeptidase: biological activities and X-ray structures of oxazole hydroxamate-EcMetAP-Mn complexes
ChemMedChem2012, 7 (6), 1020-30.

Goemaere, E.; Melet, A.; Larue, V.; Lieutaud, A.; Alves de Sousa, R.; Chevalier, J.; Yimga-Djapa, L.; Giglione, C.; Huguet, F.; Alimi, M.; Meinnel, T.; Dardel, F.; Artaud, I.; Pages, J. M.,
New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity
J. Antimicrob. Chemother.2012, 67 (6), 1392-400.

Galardon, E.; Roger, T.; Deschamps, P.; Roussel, P.; Tomas, A.; Artaud, I.,
< i>Synthesis of a Fe(II)SH complex stabilized by an intramolecular N-H...S hydrogen bond, which acts as a H2S donor
Inorg Chem 2012, 51 (19), 10068-70.

Dansette, P. M.; Rosi, J.; Debernardi, J.; Bertho, G.; Mansuy, D.,
Metabolic activation of prasugrel: nature of the two competitive pathways resulting in the opening of its thiophene ring
Chem Res Toxicol2012, 25 (5), 1058-65.

Dansette, P. M.; Rosi, J.; Bertho, G.; Mansuy, D.,
Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer
Chem Res Toxicol2012, 25 (2), 348-56.

Beziere, N.; Decroos, C.; Mkhitaryan, K.; Kish, E.; Richard, F.; Bigot-Marchand, S.; Durand, S.; Cloppet, F.; Chauvet, C.; Corvol, M. T.; Rannou, F.; Xu-Li, Y.; Mansuy, D.; Peyrot, F.; Frapart, Y. M.,
First combined in vivo X-ray tomography and high-resolution molecular electron paramagnetic resonance (EPR) imaging of the mouse knee joint taking into account the disappearance kinetics of the EPR probe
Mol Imaging2012, 11 (3), 220-8.

Alimi, M.; Allam, A.; Selkti, M.; Tomas, A.; Roussel, P.; Galardon, E.;Artaud, I.,
Characterization of cobalt(III) hydroxamic acid complexes based on a tris(2-pyridylmethyl)amine scaffold: reactivity toward cysteine methyl ester
Inorg Chem 2012, 51 (17), 9350-6.

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