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PRESTAT Guillaume

Professor

publié le , mis à jour le


Université Paris Descartes
45 rue des Saints-Pères
75006 Paris
UMR8601
Organic synthesis for biomedical research
Door R106ter, 1st floor
Tel. : +33 (0)1 42 86 41 89
Contact : Guillaume Prestat

 
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Short CV

 

2011 - Professor Organic Chemistry - Université Paris Descartes
2010 - Actelion Chair in innovative organic chemistry
2006 - Habilitation à diriger des recherches, Université Paris VI -Palladium-catalyzed cyclizations and domino processes.
2000 - Assitant Professor - Université Pierre et Marie Curie Paris VI - IPCM - Team Pr. Giovanni Poli
1998-2000 - Post-roctoral research - Tital synthesis of actegenins via ring-closing metathesis - Dr Charles Mioskowski CEA Saclay - Service des Molécules Marquées.
1997-98 - ATER Faculté des sciences et technique de l'Université de Nantes
1998 - PhD Thesis : Synthesis of thiodésoxynucleosides - Dr Jean-Paul Pradère e

 

Research topics


 

Organometallic catalysis and domino reactions

Our research program focuses on new synthetic methodologies based on atom an step economical reactions. To this extent, we develop new domino transition metal-catalyzed domino reactions allowing the access to privileged structure in medicinal chemistry.

 

Medicinal Chemistry : FGFR3 Inhibitors

FGFR3 is a receptor for fibroblast growth factors having a tyrosine kinase activity. Activating mutations of FGFR3 are responsible for certain cancers (bladder, cervical, ...) and a set of abnormal bone growth variable severity (achondroplasia, thanatophoric dwarfism, ...). We are developing the synthesis of several families of molecules to selectively inhibit the kinase activity of FGFR3.

 

Book chapters


 

1) “Selectivity in Palladium Catalyzed Allylic Substitution” in Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis (Kazmaier U. Ed), Topics in Organometallics Chemistry 38, pp 1-64, Springer-Verlag Berlin and Heidelberg GmbH & Co. Kammerer-Pentier, C.; Liron, F.; Prestat, G.; Poli, G
2) “The Fabulous Destiny of Sulfenic Acids” in Innovative Catalysis in Organic Synthesis: Oxidation, Hydrogenation, and C-X Bond Forming Reactions (Andersson, P. G. Ed), pp 47-103, Wiley-VCH Verlag GmbH & Co. KGaA Avers, M.C.; Bonaccorsi, P.; Madec, D.; Prestat, G.; Poli, G


Publications


 


«Synthesis of Six- and Seven-Membered Chloromethyl-Substituted Heterocycles via Palladium-Catalyzed Amino- and Oxychlorination»
Manick, A.-D.; Berhal, F.; Prestat, G.
Synthesis 2016, 48, 3719-3729.
«Copper(I)/Copper(II)-Assisted Tandem Catalysis: The Case Study of Ullmann/Chan-Evans-Lam N1,N3-Diarylation of 3-Aminopyrazole»
Beyer, A.; Castanheiro, T.; Busca, P.; Prestat, G.
Chem. Cat. Chem. 2015, 7, 2433-2436.
«Molecular modeling study of the induced-fit effect on kinase inhibition: the case of fibroblast growth factor receptor 3 (FGFR3)»
BLi, Y.; Delamar, M.; Busca, P.; Prestat, G.; Le Corre, L.; Legeai-Mallet, L.; Hu, R.; Zhang, R.; Barbault, F.
J Comput Aided Mol Des 2015, 29, 619-641.
« Microwave-assisted preparation of 4-amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as building blocks for the diversity-oriented synthesis of pyrazole-based polycyclic scaffolds»
Le Corre, L.; Tak-Tak, L.; Guillard, A.; Prestat, G.; Gravier-Pelletier, C.; Busca, P.
Org. Biomol. Chem. 2015, 13, 409-423.
«Synthesis of γ-Lactams and γ-Lactones via Pd-Catalyzed Allylations»
Kammerer, C.; Prestat, G.; Madec, D.; Poli, G. Acc. Chem. Res. 2014, 47, 3439-3447.
« Synthesis of 1,4-benzodiazepinones and 1,4-benzoxazepinones via palladium catalyzed amino and oxyacetoxylation»
Manick, A.-D.; Duret, G.; Berhal, F.; Prestat, G. Org. Chem. Front. 2014, 1, 1058-1061.
« Dormant versus Evolving Aminopalladated Intermediates: Toward a Unified Mechanistic Scenario in Pd(II)-Catalyzed Aminations »
Rajabi, J. Lorion, M.; Ly, V.L.; Liron, F.; Oble, J.; Prestat, G.; Poli, G.
Chem. Eur. J. 2014, 20, 1539-1546.
«Reactivity of tert-butanesulfinamides in palladium-catalyzed allylic substitutions»
Mistico, L.; Huynh, V.; Bourderioux, A.; Chemla, F.; Frerreira, F.; Oble, J.; Perez-Luna, A.; Poli, G.; Prestat, G.
J. Organomet. Chem. 2014, 760, 124-129.
« Synthesis of 1,4-benzodiazepinones via palladium-catalysed allene carbopalladation/amination domino sequence»
Rigamonti, M.; Prestat, G.; Broggini, G.; Poli, G.
J. Organomet. Chem. 2014, 760, 149-155.
« Pd-Catalyzed Domino Carbonylative / Decarboxylative Allylation: An Easy and Selective Monoallylation of Ketones »
Giboulot, S.; Liron, F.; Prestat, G.; Wahl, B.; Sauthier, M.; Castanet, Y.; Mortreux, A.; Poli, G.
Chem. Commun. 2012, 48, 5889-5891.
« Dual Reactivity of O-α-Allenyl Esters Under Palladium(0) Catalysis: From Carbopalladation/Allylic alkylation Domino Sequence to Decarboxylative Allenylation »
Kammerer-Pentier,C.; Diez Martinez, A.; Oble, J.; Prestat, G. Merino,G.; and Poli, G.
J. Organomet. Chem. 2012, 714, 53-59
« Pd-catalyzed Asymmetric Synthesis of N-Allenyl Amides and their Au-catalyzed Cycloisomerizative Hydroalkylation: a New Route Toward Enantioenriched Pyrrolidones »
Boutier, A.; Kammerer-Pentier, C.; Krause, N.; Prestat, G.; Poli, G.
Chem. Eur. J. 2012, 18, 3840-3844.
« Palladium-Catalyzed Allylic Sulfinylation and the Mislow-Braverman-Evans Rearrangement»
Kleimark, J.; Prestat, G. Poli, G.; P.-O. Norrby
Chem. Eur. J. 2011, 17, 13963-13965.
« Palladium-Catalyzed Aromatic Sulfonylation: A New Catalytic Domino Process Exploiting in situ Generated Sulfinate Anions»
Le Duc, G.; Bernoud, E.; Prestat, G.; Cacchi, S.; Fabrizi, G.; Madec, D.; Poli, G.
Synlett 2011, 2943-2946.
« Cavitand supported tetraphosphine: cyclodextrin offers a useful platform for Suzuki-Miyaura cross-coupling »
Zaborova, E.; Deschamps, J.; Guieu, S.; Blériot, Y.; Poli, G.; Ménand, M.; Madec, D.; Prestat, G.; Sollogoub, M.
Chem. Commun. 2011, 47, 9206-9208.
Sélectionné par ChemInform Editor's Choice 2011, 42(48)
« γ- and δ-Lactams via Palladium-Catalyzed Intramolecular Allylic Alkylation: Enantioselective Synthesis, NMR Investigations, and DFT Rationalization»
Bantreil, X.; Prestat, G.; Moreno, A.; Madec, D.; Fristrup, P.; Norrby, P.-O.; Pregosin, P.S.; Poli, G
Chem. Eur. J. 2011, 17, 2885-2896.