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PADOVANI Dominique

Chargé de Recherche

publié le , mis à jour le

Université Paris Descartes
45 rue des Saints-Pères
75006 Paris
Chimie Bio-inorganique des Dérivés Soufrés et Pharmacochimie
Porte R125/169/120, 1er étage
Tél. : +33 (0)1 42 86 20 86
Contact : PADOVANI Dominique

Research area.

Chemical Biology and Molecular Tools for Sulfur Metabolic Compounds

Scientific Carreer:
  • Researcher CR1 CNRS (Section 16), UMR 8601 CNRS-Paris Descartes (since 2012) (Team: Bio-inorganic Chemistry of Sulfur Metabolic Compounds and Pharmacochemistry)

  • Post-doctoral fellow (ARC fellowship), LEBS, CNRS, Gif/Yvette (2009-2011) (Supervisor: J. Cherfils)

  • Research Investigator, University of Michigan, USA (2007-2009) (Supervisor: R. Banerjee)

  • Post-doctoral fellow, University of Nebraska Lincoln, USA (2003-2007) (Supervisor: R. Banerjee)

  • PhD in Structural and Functional Biology (MENRT scholarship), University J. Fourier, Grenoble (2002) (Directors: M. Fontecave and E. Mulliez)

  • BSc in Biochemistry, University of Burgundy, Dijon (1997) with a one year training period in Fournier Pharma GmbH, Heidelberg, Germany (Supervisor: J.-L. Dasseux)

  • Master of Chemistry oriented towards Life Sciences: M2 “Frontiers in Chemistry” (Bio-organic chemistry) and M2 “Molecular Chemistry” (Bio-inorganic chemistry) - Paris Descartes University (since 2013)

  • Master of Biology Health: M2 “Cellular Signaling and Neurosciences” (Sulfur metabolic compounds and H2S signaling) - Paris-Saclay University (since 2014)

  • Master of Chemistry oriented towards Life Sciences: M1 “Frontiers in Chemistry” (Bio-inorganic chemistry) - Paris Descartes University (since 2016)

Scientific interests :

Chemical biology, bio-inorganic chemistry, bio-organic chemistry (redox, radical and PLP-dependent), biochemistry and signaling of H2S (persulfides and polysulfides), sulfur-compounds metabolism.

Bibliography (main publications) :

Sulfur metabolic compounds

  • Padovani D. (2017) A new link between high homocysteine levels, cancers and neurodegenerative diseases. Med Sci (Paris) 33:494-497.

  • Galardon E. et al (2017) Reactions of persulfides with the heme cofactor of oxidized myoglobin and microperoxidase 11: reduction or coordination. Dalton Trans. 46:7939-7946

  • Padovani D. et al (2016) Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases. Nat. Commun. 7:13386.

    See in En direct des laboratoires de l'institut de Chimie : « L’homocystéine impliquée dans certains cancers et la maladie de Parkinson » 16 novembre 2016

  • Galardon E and Padovani D (2015) Reactivity of Persulfides Towards Strained Bicyclo[6.1.0]nonyne Derivatives: Relevance to Chemical Tagging of Proteins. Bioconjug Chem 26: 1013-1016.

  • Terzić V et al (2014) Electrophilic sulfhydration of 8-nitro-cGMP involves sulfane sulfur. Org Biomol Chem 12: 5360-5364

  • Singh S et al (2009) Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions. J Biol Chem 284: 22457-22466

  • Chiku T*, Padovani D*, Zhu W* et al (2009) H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem 284: 11601-11612

Arf GTPases and their exchange factors
  • Padovani D et al (2014) EFA6 controls Arf1 and Arf6 activation through a negative feedback loop. Proc Natl Acad Sci USA 111: 12378-12383

B12 trafficking
  • Lofgren M et al (2013) A switch III motif relays signaling between a B12 enzyme and its G-protein chaperone. Nat Chem Biol 9: 535-539

    See in News & Views: Toraya T. (2013) G-protein signaling: A switch saves B12 radical status. Nat Chem Biol 9:530-1.

  • Padovani D and Banerjee R (2009) A G-protein editor gates coenzyme B12 loading and is corrupted in methylmalonic aciduria. Proc Natl Acad Sci USA 106: 21567-21572

    See in Editor’s choice: Cobalt Ins and Outs. Science (2009) 326: 1591

  • Padovani D and Banerjee R (2009) A rotary mechanism for coenzyme B12 synthesis by adenosyltransferase. Biochemistry 48: 5350-5357

    See in Editor’s choice: Cobalt Ins and Outs. Science (2009) 326: 1591

  • Padovani D et al (2008) Adenosyltransferase tailors and delivers coenzyme B12. Nat Chem Biol 4: 194-196

    See in News & Views: Bandarian V. (2008) Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase. Nat. Chem. Biol. 4:158-159

  • Padovani D et al (2006) Energetics of interaction between the G-protein chaperone, MeaB, and B12-dependent methylmalonyl-CoA mutase. J Biol Chem 281: 17838-17844

Radical Chemistry (B12 and iron sulfur clusters)
  • Padovani D and Banerjee R (2006) Alternative pathways for radical dissipation in an active site mutant of B12-dependent methylmalonyl-CoA mutase. Biochemistry 45: 2951-2959

  • Gambarelli S et al (2005) Activation of the anaerobic ribonucleotide reductase by S-adenosylmethionine. Chembiochem 6: 1960-1962

  • Padovani D et al (2001) Activation of class III ribonucleotide reductase from E. coli. The electron transfer from the iron-sulfur center to S-adenosylmethionine. Biochemistry 40: 6713-6719