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CV Méla : anglais

Université Paris Descartes

45 rue des Saints-Pères

75006 Paris


Chemistry of RNAs, nucleosides, Peptides and Heterocycles

Door R273, 2nd floor

Tel. : +33 (0)1 42 86 40 26


Curriculum vitae

2012 - Professor of chemistry (section 32) - Université Paris Descartes

2009 - Habilitation à diriger des recherches, Université Pierre & marie Curie - " Porphyrines, Carbohydrates and Nucleosides chemistry for synthesis of Biomolecules".

2009 - Assistant Professor - Université Pierre et Marie Curie Paris VI - UMR 7201-IPCM - Team "Glycochimie Organique, Biologique et Supramoléculaire", Pr. Matthieu Sollogoub

2000 - Assistant Professor - Université Pierre et Marie Curie Paris VI - UMR 7613, Team "Chimie des Glucides", Pr. Jean-Marc Valéry

1998-99 - ATER-Université Pierre et Marie Curie Paris VI - UMR 7613, Team "Chimie des Glucides", Pr. Jean-Marc Valéry

1998 - Post-Doctoral fellow -University of California, Santa Barbara, USA, Laboratoire du Pr. Bruce Lipshutz

1997- Post-Doctoral fellow- Stanford University, California, USA, Laboratoire du Pr. Jim Collman

1997 - Ph.D : "Etude de l’atropoisomérisation des tétrakis(o-nitrophényl) porphyrines et synthèses de modèles d’hémoproteines".- Dr Eric Rose, Université Pierre et Marie Curie Paris VI


Chapter of books

  • Covalent functionalization of nucleic acids, M. Arthur & M. Etheve-Quelquejeu, In Chemistry of Organo-Hybrids : Synthesis and Characterization of Functional Nano-Objects ; Lacôte, E. ; Charleux, B. ; Copéret, C. ; Eds. ; Wiley-VCH, 2015.

Major Publications

  • N. Bhattacharjee, S. Triboulet, V. Dubée, M. Fonvielle, Z. Edoo, J-E. Hugonnet, M. Ethève-Quelquejeu, J-P. Simorre, M. J. Field, M. Arthur, C. M. Bougault, Negative impact of carbapenem methylation on the reactivity of β-lactams for cysteine acylation revealed by quantum calculations and kinetic analyses

Antimicrob. Agents Chemother., 2019, DOI : 10.1128/AAC.02039-18.

  • Stephanie Oerum, Marjorie Catala, Colette Atdjian, Franck Brachet, Luc Ponchon, Pierre Barraud, Laura Iannazzo, Louis Droogmans, Emmanuelle Braud, Mélanie Ethève-Quelquejeu, Carine Tisné, Bisubstrate analogues as structural tools to investigate mA methyltransferase active sites

RNA Biology, 2019, 16, 798-808, DOI : 10.1080/15476286.2019.1589360.

  • Triboulet, S. ; Edoo, Z. ; Compain, F. ; Ourghanlian, C. ; Dupuis, A. ; Dubée, V. ; Sütterlin, L. ; Atze, H. ; Etheve-Quelquejeu, M. ; Hugonnet, J-E. ; Arthur, M. Tryptophan fluorescence quenching in β-lactam-interacting proteins is modulated by the structure of intermediates and final products of the acylation reaction

ACS Infectious Diseases, 2019, doi : 10.1021/acsinfecdis.9b00023.

  • Fonvielle M*., Bouhss A., Hoareau C., Patin D., Mengin-Lecreulx D., Iannazzo L., Sakkas N., El Sagheer A., Brown T., Ethève-Quelquejeu M*., Arthur M.*, Synthesis of SAM-adenosine conjugates for the study of m6A-RNA methyltransferases,

Chem. Eur. J. , 2018,

  • C. Atdjian, L. Iannazzo, E. Braud*, M. Etheve-Quelquejeu*, Synthesis of SAM-adenosine conjugates for the study of m6A-RNA methyltransferases,

Europ. J. Org. Chem. , 2018,

  • E. Yen-Pon, B. Li, M. Acebrón-Garcia de Eulate, C. Tomkiewicz-Raulet, J. Dawson, D. Lietha, M. C. Frame, X. Coumoul, C. Garbay, M. Etheve-Quelquejeu, H. Chen*, Structure-based design, synthesis and characterization of the first irreversible inhibitor of Focal Adhesion Kinase,

ACS Chem. Biol, 2018, doi : 10.1021/acschembio.8b00250.

  • Z. Edoo, L. Iannazzo, F. Compain, H. van Tilbeurgh, I. Li dela Sierra Galay, M. Fonvielle, M. Arthur*, M. Ethève-Quelquejeu*, J-E. Hugonnet*, Synthesis of avibactam derivatives and activity on β-lactamases and peptidoglycan biosynthesis enzymes of mycobacteria,

Chem. Eur. J. , 2018, 24, 8081-8086.

  • L. Iannazzo, M. Fonvielle, E. Braud, H. Hrebabecky, E. Prochazkova, R. Nencka, C. Mathé, M. Arthur, M. Etheve-Quelquejeu*, Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes,

Org. Biomol. Chem. , 2018, 16, 1903-1911.

  • F. Ngadjeua, E. Braud, S. Saidjalolov, L. Iannazzo, D. Schnappinger, S. Ehrt, J-E. Hugonnet, D. Mengin-Lecreulx, D. Patin, M. Ethève-Quelquejeu*, M. Fonvielle*, M. Arthur,* Critical impact of peptidoglycan precursor amidation on the activity of L,D-transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis.

Chem. Eur J., 2018, DOI : 10.1002/chem.201706082.

  • P. Dao, D. Lietha, M. Etheve-Quelquejeu, C. Garbay, H. Chen*, Bioorg. Med. Chem. Lett., 2017, 27(8):1727-1730., Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity,

Bioorg. Med. Chem. Lett., 2017, 27(8), 1727-1730.

  • M. Sarkis, M.A. Miteva, M. Chiara Dasso Lang, M. Jaouen, M-A. Sari, M-O. Galcéra, M. Ethève-Quelquejeu, C. Garbay, G. Bertho, E. Braud*, Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25,

PROTEINS : Struct., Funct., Bioinf., 2017, 55, 13553-13557.

  • M. Fonvielle, N. Sakkas, L. Iannazzo, C. Le Fournis, D. Patin, D. Mengin-Lecreulx, A. El-Sagheer, E. Braud, S. Cardon, T. Brown, M. Arthur*, M. Etheve-Quelquejeu*, Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes,

Angewandte Chem., 2016, 55, 13553-13557.

  • L. Le Corre, M. Chiara Dasso Lang, C. Garbay, C. Gravier-Pelletier, P. Busca, M.Ethève-Quelquejeu, E. Braud*, Synthesis of Multifunctionalized 2-Iminothiazolidin-4-ones and Their 2-Arylimino Derivatives" synthesis,

Synthesis, 2016, 48(24) : 4569-4579.

  • L. Iannazzo, D. Soroka, S. Triboulet, M. Fonvielle, F. Compain, V. Dubée, J-L. Mainardi, J-E. Hugonnet, E. Braud, M. Arthur*, M. Etheve-Quelquejeu*, Routes of synthesis of carbapenems for optimizing both the inactivation of L,D-transpeptidase LdtMt1 of Mycobacterium tuberculosis and the stability towards hydrolysis by β-lactamase BlaC,

J. Med. Chem., 2016, DOI : 10.1021/acs.jmedchem.6b00096.

  • L. Iannazzo, E. Benedetti*, M. Catala, M. Etheve-Quelquejeu, C. Tisné, L. Micouin*, Monitoring of reversible boronic acid-diol interactions by fluorine NMR spectroscopy in aqueous media,

Org. Biomol. Chem., 2015, 13, 8817-8821.

  • L. Iannazzo, G. Laisné, M. Fonvielle, E. Braud, J-P. Herbeuval, M. Arthur*, M. Etheve-Quelquejeu*, Synthesis of 3’-Fluoro-tRNA Analogues to explore non-ribosomal peptide synthesis in bacteria,

ChemBioChem, 2015, 16, 477-486.(VIP Paper, inside cover).

  • M. Santarem, M. Fonvielle, N. Sakkas, G. Laisné, M. Chemama, J-P. Herbeuval, E. Braud, M. Arthur, M. Etheve-Quelquejeu*, Synthesis of 3’-triazoyl-dinucleotides as precursors of stable Phe-tRNAPhe and Leu-tRNALeu analogues,

Bioorg. Med. Chem. Lett., 2014, 24, 3231 - 3233.

  • B. Xu, L. Unione, J. Sardinha, S. Wu, M. Ethève-Quelquejeu, A. Pilar Rauter, Y. Blériot, Y. Zhang, D. Diaz, J. Jiménez-Barbero, M. Sollogoub*, Gem-difluoro-carbadisaccharides, restoring the exo-anomeric effect ;

Angewandte Chem., 2014, 53, 9597-9602.

  • D. Mellal, M. Fonvielle, M. Santarem, M. Chemama, Y. Schneider, L. Iannazzo, E. Braud, M. Arthur*, M. Etheve-Quelquejeu*, Synthesis and Biological Evaluation of Non-isomerizable Analogues of Ala-tRNAAla ;

Org. Biomol. Chem., 2013, 11 (36), 6161 - 6169. (Selected as an Org. & Biomol. Chem. Hot Article).

  • M. Fonvielle, I. Li de la Sierra-Gallay, A. El-Sagheer, M. Lecerf, D. Patin, D. Mellal, C. Mayer, D. Blanot, N. Gale, T. Brown, H. van Tilbeurgh, M. Ethève-Quelquejeu,* M. Arthur*, The Structure of FemXWv in Complex with a Peptidyl-RNA Conjugate Reveals the Mechanism of Aminoacyl Transfer from Ala-tRNAAla to Peptidoglycan Precursors

Angewandte Chem., 2013, 125, 7419-7422.

  • S. Triboulet, V. Dubée, L. Lecoq, C. Bougault, J-L. Mainardi, L. B. Rice, M. Ethève-Quelquejeu, L. Gutmann, A. Marie, L. Dubost, J-E. Hugonnet, J-P. Simorre*, M. Arthur*, Kinetic features of L,D-transpeptidase inactivation critical for β-lactam antibacterial activity

PLOS ONE, 2013, 8, e67831.

  • Leclerc E., Pannecoucke X., Etheve-Quelquejeu M., Sollogoub M., Fluoro-C-glycosides and fluoro-carbasugars, hydrolytically stable and synthetically challenging glycomimetics.

Chem. Soc. Rev., 2013, 42, 4270-4283.

  • Fonvielle M., Mellal D., Patin D., Lecerf M., Blanot D., Bouhss A., Santarem M., Mengin-Lecreulx D. Sollogoub M., Arthur* M., Ethève-Quelquejeu* M., Efficient Access to Peptidyl-RNA Conjugates for Picomolar Inhibition of Non-ribosomal FemXWv Aminoacyl Transferase.

Chem. Eur. J., 2013, 19, 1357-1363. (Selected as an Wiley "Hot Topic") .

  • V. Dubee, S. Triboulet, J-l. Mainardi, M. Ethève-Quelquejeu, L. Gutmann, A. Marie, L. Dubost, J-E. Hugonnet, M. Arthur, Inactivation of Mycobacterium tuberculosis L,D-transpeptidase LdtMt1 by carbapenems and cephalosporins,

Antimicrob. Agents Chemother. 2012, 56(8):4189.

  • Dubée, V ; Arthur, M ; Fief, H ; Triboulet, S ; Mainardi, J.-L ; Gutmann, L ; Sollogoub, M ; Rice, L-B ; Ethève-Quelquejeu, M* ; Hugonnet, J-E*,Kinetic Analysis of Enterococcus faecium L,D-transpeptidase Inactivation by carbapenems,

Antimicrob. Agents Chemother. 2012, 56, 3409-3412.

  • E. Rose N. Raoult, E. Gallo, B. Boitrel, L. Dubois, M. Etheve-Quelquejeu, J. Pecaut, Crystal structure of a chiral binaphthyl porphyrin,

J. Porph. Phthal . 2012, 16, 324-330.

  • Fonvielle, M ; Chemama, M ; Lecerf, M ; Villet, R ; Busca, P ; Bouhss, A ; Etheve-Quelquejeu, M* ; Arthur, M* , Decoding the Logic of the tRNA Regiospecificity of Nonribosomal FemXWv Aminoacyl Transferase,

Angew. Chem. Int .Ed. 2010, 49, 5115-5119 .

  • Fonvielle, M ; Chemama, M ; Villet, R ; Lecerf, M ; Bouhss, A ; Valery, J-M ; Etheve-Quelquejeu, M ; Arthur, M*, Aminoacyl-tRNA recognition by the FemXWv transferase for bacterial cell wall synthesis,

Nucleic Acids Research 2009, 5, 1589.

  • Chemama, M ; Fonvielle, M ; Arthur, M ; Valéry, J.-M ; Etheve-Quelquejeu M* Synthesis of Stable Aminoacyl-tRNA Analogues Using Triazole as Bioisoster of Esters,

Chem. Eur. J. 2009, 15, 1929 - 1938.

  • Chemama, M ; Fonvielle, M ; Villet R. Arthur, M ; Valéry, J.-M ; Etheve-Quelquejeu M*, Stable Analogues of Aminoacyl-tRNA For Inhibition of an Essential Step of Bacterial Cell Wall Synthesis,

J. Am. Chem. Soc. 2007, 129, 12642-12643.