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Home > Research groups > New synthetic methods for the chemistry/biology interface > Research

Diversity-oriented-synthesis of cyclic polyamines

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Our team is interested in the asymmetric synthesis of cyclic polyamines. In particular, we focus our attention on the preparation of five- or six-membered rings containing 1,3-diamine motifs for the following reasons:

  • Cyclic 1,3-diamines are found in a large amount of molecules possessing interesting biological activities, such as, for example, the ability to interfere with kinases, glycosidases, CNS receptors and various enzymes

  • Differently substituted polyamines can be considered as versatile water-soluble building blocks for the design of active substances by a fragment-based approach

  • Polyamines can serve as ligands for organometallic complexes.


  • Pérez Luna, A.; Ceschi, M.-A.; Bonin, M.; Micouin, L.; Husson, H.-P.; Gougeon, S.; Estenne Bouhtou, G.; Marabout, B.; Sevrin, M.; George, P. J. Org. Chem. 2002, 67, 3522.

  • Pérez Luna, A.; Bonin, M.; Micouin, L.; Husson, H.-P. J. Am. Chem. Soc. 2002, 124, 12098.
  • Pérez Luna, A.; Cesario, M.; Bonin, M.; Micouin L. Org. Lett. 2003, 5, 4771.
  • Bournaud, C.; Robic, D.; Bonin, M.; Micouin, L. J. Org. Chem. 2005, 70, 3316.
  • Bournaud, C.; Falciola, C.; Lecourt, T.; Rosset, S.; Alexakis A.; Micouin L. Org. Lett. 2006, 8, 3581.
  • Bournaud, C.; Bonin, M.; Micouin, L. Org. Lett. 2006, 8, 3041.
  • Bournaud, C.; Chung, F.; Perez Luna, A.; Pasco, M.; Errasti, G.; Lecourt, T.; Micouin, L. Synthesis 2009, 869-887.
  • Palais, L.; Bournaud, C.; Micouin, L.; Alexakis, A. Chem. Eur. J. 2010, 16, 2567-2573. - Blond, A.; Dockerty, P.; Álvarez, R.; Turcaud, S.; Lecourt, T.; Micouin, L. J. Org. Chem. 2013, 78, 12226-12242
  • Gordillo, P.; Clerici, P.; Micouin, L. J. Org. Chem. 2017, 82, 7689-7694.