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Accueil > Equipes de recherche > Chimie Bio-inorganique des Dérivés Soufrés et Pharmacochimie

Chimie Bio-inorganique des Dérivés Soufrés et Pharmacochimie

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Direction de l’équipe : Marie-Agnès SARI

Our research area is at the interface of biochemistry, analytical biochemistry, bio(in)organic chemistry, and pharmaceutical chemistry. The work of our multidisciplinary team focuses on decrypting the reaction mechanisms of several proteins involved in metabolism (Cytochromes P450 and Paraoxonase-1), protein and nucleic glycation repair (DJ-1/PARK7), and formation of gaseous signaling molecules such as NO and H2S. In addition, our work consists in deciphering the intrinsic molecular properties, signaling functions, metabolism and/or toxicological effects of small molecular compounds (antibacterial agents, reactive sulfide species, NO, anti-thrombotic drugs, and peptides such as hepcidin).

As such, our current work can be divided into two main axes :

  1. Pharmaceutical chemistry

    • Cytochromes P450 (human orphan P450 2U1 and C. elegans P450s related to the AhR receptor)

    • Repair of protein and nucleic acid by DJ-1/Park7

    • Design and synthesis of new drugs and inhibitors (metallodrugs and NADPH analogs)

    • Metabolic activation of anti-thrombotic drugs

  2. Redox homeostasis and bio(in)organic chemistry of sulfur species

    • Properties and signaling functions of reactive sulfur species

    • Hepcidin and iron homeostasis