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Accueil > Equipes de recherche > Chimie des ARN, nucléosides, peptides et hétérocycles > Thèmes de recherche

Chemistry of RNAs

publié le , mis à jour le

Angewandte Chem. Int. Ed., 2016, 55, 13553-13557

Org. Biomol. Chem., 2015, 13, 8817-8821

Chembiochem, 2015, 16, 477-486


The Structure of FemXWv in Complex with a Peptidyl-RNA Conjugate Reveals the Mechanism of Aminoacyl Transfer from Ala-tRNAAla to Peptidoglycan Precursors
M. Fonvielle, I. Li de la Sierra-Gallay, A. El-Sagheer, M. Lecerf, D. Patin, D. Mellal, C. Mayer, D. Blanot, N. Gale, T. Brown, H. van Tilbeurgh, M. Ethève-Quelquejeu,* M. Arthur*,
Angewandte Chem., 2013, 125, 7419-7422

Efficient Access to Peptidyl-RNA Conjugates for Picomolar Inhibition of Non-ribosomal FemXWv Aminoacyl Transferase
M. Fonvielle, D. Mellal, D. Patin, M. Lecerf, D. Blanot, A. Bouhss, M. Santarem, D. Mengin-Lecreulx,, M. Sollogoub, M. Arthur, M. Ethève-Quelquejeu.
Chem. Eur. J. 2013, 19, 1357-1363
DOI: 10.1002/chem.201201999.
(Selected as an Wiley “Hot Topic”)

Org. Biomol. Chem, 2013, 11(36), 6161-6169
(Selected as an Org.&biomol. Chem >, Hot Article).

Decoding the Logic of the tRNA Regiospecificity of Nonribosomal FemXWv Aminoacyl Transferase
M. Fonvielle, M. Chemama, M. Lecerf, R. Villet, P. Busca, A. Bouhss, M. Etheve-Quelquejeu, M. Arthur,
Angew. Chem. Int .Ed., 2010, 49, 5115-5119.

Synthesis of Stable Aminoacyl-tRNA Analogues Containing Triazole as a Bioisoster of Esters
Maryline Chemama, Matthieu Fonvielle, Michel Arthur, Jean-Marc Valéry, Mélanie Etheve-Quelquejeu.
Chem. Eur. J., 2009, 15, 1929 - 1938.
DOI : 10.10002/chem..200801563

Aminoacyl-tRNA recognition by the FemXWv transferase for bacterial cell wall synthesis
Matthieu Fonvielle, Maryline Chemama, Régis Villet, Maxime Lecerf, Ahmed Bouhss, Jean-Marc Valéry, Mélanie Ethève-Quelquejeu and Michel Arthur
Nucleic Acids Research 2009 37(5):1589-1601;
DOI: 10.1093/nar/gkn1039

Idiosyncratic features in tRNAs participating in bacterial cell wall synthesis
Régis Villet, Matthieu Fonvielle, Patricia Busca, Maryline Chemama, Antoine P. Maillard, Jean-Emmanuel Hugonnet, Lionel Dubost, Arul Marie, Nathalie Josseaume, Stéphane Mesnage, Claudine Mayer, Jean-Marc Valéry, Mélanie Ethève-Quelquejeu, Michel Arthur.
Nucleic Acids Research 2007 35(20):6870-6883;
DOI: 10.1093/nar/gkm778

 

Model of FemXWv-tRNAAla interaction
Ala-tRNAAla analogue obtained by Semi-synthesis
η6-(Arene)tricarbonylchromium and Manganese Complexes Linked to 2‘-Deoxyuridine
Mélanie Etheve-Quelquejeu, Jean-Philippe Tranchier, Françoise Rose-Munch, Eric Rose, Lieve Naesens, Erik De Clercq
Organometallics, 2007, 26 (23), pp 5727-5730
DOI: 10.1021/om700674v

 

 

 

Stable Analogues of Aminoacyl-tRNA for Inhibition of an Essential Step of Bacterial Cell-Wall Synthesis
Maryline Chemama, Matthieu Fonvielle, Régis Villet, Michel Arthur, Jean-Marc Valéry, Mélanie Etheve-Quelquejeu
J. Am. Chem. Soc., 2007, 129 (42), pp 12642-12643
DOI: 10.1021/ja0749946