Nos tutelles


Nos partenaires


Connection issue?

Accueil > People


Assistent Professor

publié le , mis à jour le

Université Paris Descartes
45 rue des Saints-Pères
75006 Paris
Organic synthesis for biomedical research
Door R161, 1st floor
Tel. : +33 (0) 1 42 86 21 81
Contact : Calvet-Vitale Sandrine

  • Member French Chemical Society


Curriculum Vitae

Assistant Professor (2007 - ...) - Paris Descartes University - UMR 8601.

Postdoctoral studies (2007) - Paris Descartes University Postdoctoral studies (2006) - Amsterdam Postdoctoral studies Pierre et Marie Curie Universitéy “News pathways towards chiral heterocyclic enaminoesters. Application to the synthesis of functionnalized pyrrolidines and piperidines ”, Supervisors Pr G. Lhommet and Dr C. Vanucci-Bacqué (Organic Chemistry laboratory).



Research Topics

Chimie médicinale

  • Design and synthesis of news MraY inhibitors.
Antimicrobial resistance, and especially the resistance of bacteria to antibiotics, is a major public health problem. One way to fight resistant bacteria and to delay the emergence of resistance is to develop new antibiotics towards enzymes that are not targeted by commercial drugs. The bacterial transferase MraY catalyzes the first membrane-associated step in the peptidoglycan biosynthesis. No drug targets this enzyme which is ubiquitous and essential in bacteria, making MraY a promising target for the discovery of new antibiotics. Few 3D structures of MraY have been published and allow the rational design of inhibitors.



We are developing convergent synthetic pathways to prepare efficiently elaborated molecules that are either simplified analogs of naturally occurring MraY inhibitors or based on new core structures identified by virtual High Throughput screening. The inhibitory activity of all synthetized compounds towards MraY is evaluated thanks to a collaboration with I2BC UMR 9198 (T. Meinnel) CEA-CNRS- Paris-Sud University, Team « Enveloppes Bactériennes et Antibiotiques ».




"Effect of uridine protecting groups on the diastereoselectivity of uridine-derived aldehyde 5'-alkynylation."
Ben Othman, R. ; Fer, M. J. ; Le Corre, L. ; Calvet-Vitale, S.* ; Christine Gravier-Pelletier, C.*
Beilstein J. Org. Chem. 2017, 13, 1533-1541.
En savoir plus
"5′-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modelling"
Fer, M. J. ; Bouhss, A. ; Patrão, M. ; Le Corre, L. ; Pietrancosta, N. ; Amoroso, A. ; Joris, B. Mengin-Lecreulx, D. ; Calvet-Vitale, S.* ; Christine Gravier-Pelletier, C.*
Org. Biomol. Chem. 2015, 13, 7193-7222.
En savoir plus
"A Diastereoselective Synthesis of 5′-Substituted-Uridine Derivatives"
Fer, M. J.; Doan, P.; Prangé, T.; Calvet-Vitale, S.* ; Gravier-Pelletier, C.*
J. Org. Chem. 2014, 79, 7758-7765.
En savoir plus
"Toward Analogues of MraY Natural Inhibitors: Synthesis of 5′-Triazole-Substituted-Aminoribosyl Uridines Through a Cu-Catalyzed Azide-Alkyne Cycloaddition"
Fer M.J.; Olatunji, S.; Bouhss, A.; Calvet-Vitale, S.*; Gravier-Pelletier, C.*
J. Org. Chem. 2013, 78, 10088-10105.
En savoir plus
"Synthesis and Conformational Analysis of Fluorinated Pipecolic Acids"
Singh, S.; Martinez, C.-M.; Calvet-Vitale, S. ; Prasad, A. K.; Prangé, T.; Dalko, P. I.; Dhimane, H.*
Synlett 2012, 23, 16, 2421-2425.
En savoir plus
"Backbone Amide Linker Strategy for the Synthesis of 1,4-Triazole-Containing Cyclic Tetra- and Pentapeptides"
Springer, J.; de Cuba, K.R.; Calvet-Vitale, S.; Geenevasen, J.A.J.; Hermkens, P.H.H.; Hiemstra, H.; van Maarseveen, J.H.*
Eur. J. Org. Chem. 2008, 2592-2600
En savoir plus
"Diastereoselective Additions to (3S)-3-Aminodehydrocaprolactams: Development of a Versatile Synthesis of New Substituted Cyclic L-Lysines "
Levraud, C.; Calvet-Vitale, S. ; Bertho, G.; Dhimane, H.*
Eur. J. Org. Chem. 2008, 1901-1909.
En savoir plus
"New access to chiral pyrrolidine and piperidine β-enamino ketones. Application to the enantioselective synthesis of (-)-hygroline"
Vanucci-Bacqué, C.*; Calvet-Vitale, S.; Fargeau-Bellassoued, M.-C.; Lhommet, G.*
Arkivoc 2007, 148-161.
En savoir plus
"Diastereoselective synthesis of chiral methyl 2-piperidin-2-ylpropanoates"
Pereira, J.; Calvet-Vitale, S. ; Fargeau-Bellassoued, M.-C.; Mouries-Mansuy, V.; Vanucci-Bacqué, C.*; Lhommet, G.*
Heterocycles 2007, 71, 437-444.
En savoir plus
"Stereoselective synthesis of new chiral N-tertiary tetrasubstituted beta-enamino ester piperidines through an ammonia-catalyzed process"
Calvet-Vitale, S. ; Vanucci-Bacqué, C*.; Fargeau-Bellassoued, M.-C.; Lhommet, G.*
J. Org. Chem. 2006, 71, 2071-2077.
En savoir plus
"Silylated Vinyloxiranes - Recent Advances and Synthetic Applications"
Marion, F.; Calvet, S.; Marié, J.-C.; Courillon, C.*; Malacria, M.*
Eur. J. Org. Chem. 2006, 453-462.
En savoir plus
" Stereocontrolled reduction of chiral pyrrolidine and piperidine β-enamino esters: formal enantioselective synthesis of (+)-calvine "
Calvet-Vitale, S. ; Vanucci-Bacqué, C.; Fargeau-Bellassoued, M.-C.; Lhommet,
Tetrahedron 2005, 61, 7774-7782.
En savoir plus
"Nouvel routes to chiral 2-alkoxy-5/6-methoxycarbonylmethylidene pyrrolidines/piperidines"
David, O., Calvet, S., Chau, F.; Vanucci-Bacqué, C.; Fargeau-Bellassoued, M.-C.; Lhommet, G.*
J. Org. Chem. 2004, 69, 2888-2891.
En savoir plus
" Chiral Heterocyclic β-enamino esters: convenient synthesis and diastereoselective reduction”
Calvet, S.; David, O.; Vanucci-Bacqué, C.; Fargeau-Bellassoued, M.-C.; Lhommet, G.*
Tetrahedron 2003, 59, 6333-6339.
En savoir plus
"Highly Stereoselective Generation of α-Pyrones Displaying Four Contiguous Stereogenic Centers"
Marion, F.; Calvet, S.; Courillon, C.; Malacria, M.*
Tetrahedron Lett. 2002, 43, 3369-3371.
En savoir plus
"Diastereoselective Thiol Conjugate Addition on δ-Alkylated-γ-Silylated-α,β-Unsaturated-δ-Lactones”
Calvet, S.; Courillon, C.; Malacria, M.*
Arkivoc 2002, 189-195.
En savoir plus