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 Accueil > Équipes > Chimie Bio-inorganique des Dérivés Soufrés et Pharmacochimie > Research

 

Research

 

 

 Our group is involved in two main areas of research:

 

Chemical and Biological Studies of Biologically Active Sulfur Compounds

Chemical Biology and Molecular Tools for Sulfur Metabolic Compounds

Hepcidin

Mechanism of the metabolic activation of anti-thrombotic drugs of the thienopyridine series

 

 

Pharmaceutical Chemistry

Metalloenzymes - Pharmaco-Toxicological Implications

Design, synthesis and biological evaluation of new antibacterial agents : new strategies of vectorization of a drug to its target

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Chemical Biology and Molecular Tools for Sulfur Metabolic Compounds.

E. Galardon, D. Padovani, Isabelle Artaud, M. Dulac (PhD 2015-2018)
Collaborators :
Dr. V. Baland (LEM - Université Paris 7 - Comue SPC), Dr. F. Blachier & Dr. A. Lan (AgroParisTech), Dr. F. Bouillaud - Institut Cochin - Comue SPC), Dr. B. Chadefaux-Vekemans), Dr. X. Norel (Hôpital Bichat - Université Paris Nord), Pr. Dr. P. Hildebrandt (Technische Universität Berlin, Germany), Dr. B. Kloesh (Ludwig Boltzmann Institute for Rheumatology, Balneology (...)

 

Hepcidin.

M.A. Sari, Maryse Jaouen, Isabelle Artaud
Post-docs and PhD students : L. Khemtemourian (PostDoc 2008-2009), N. Desbenoit (PhD 2009), B. Gagliardo (PhD 2008)
Collaborations : Dr Sophie VAULONT (INSERM U567, CNRS UMR 8104, Institut Cochin)
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Etude de l’hepcidine
L’hepcidine est un petit peptide de la famille des peptides antimicrobiens produit par le foie, dont il a été montré récemment qu’il jouait un rôle clé dans l’homéostasie du fer. Cette hormone agit en régulant la quantité de fer dans l’organisme (...)

 

Design, synthesis and biological evaluation of new antibacterial agents : new strategies of vectorization of a drug to its target.

Isabelle Artaud, Rodolphe Alves de Sousa, Maryse Jaouen,Dominique Padovani, Erwan Galardon.
Post-docs and PhD students : Anas Allam (Post Doc 2010-2015) , Sandy Compain (PhD 2015), M. Alimi (PhD 2011), F. Huguet (PhD 2010), S. Petit (PhD 2007), A. Boularot (PhD 2005),
Collaborations : J.-M. Pagès (UMR-MD1 IRBA Marseille), M. Réfrégiers (Synchrotron SOLEIL Gif-sur-Yvette), T. Meinnel (ISV Gif-sur-Yvette), N. Leulliot (UMR8015 Paris Descartes)
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— Antimicrobial résistance (AMR) is a major public (...)

 

Metalloenzymes - Pharmaco-Toxicological Implications

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1- Study of a Human Orphan Cytochrome P450 : CYP 2U1. (J.-L. Boucher, K. Jradi Nouri, H. Hessani, D. Mansuy)
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The human genome has shown the existence of 57 CYPs ; 15 of them are "orphan" since almost nothing is known about their biological roles and biochemical characteristics. Among them, CYP 2U1 is predominantly expressed in the brain. Recent studies have shown greater expression of CYP 2U1 in breast and colorectal cancers than in normal tissues, and several mutations in CYP 2U1 are (...)

 

Mechanism of the metabolic activation of anti-thrombotic drugs of the thienopyridine series.

P. Dansette, D. Mansuy
Collaborations : A. Hessani (UMR 8601)
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The tetrahydrothienopyridine anti-thrombotic drugs ticlopidine, clopidogrel and prasugrel are prodrugs that must be metabolized into the pharmacologically active thiols 3 that act as irreversible inhibitors of platelet receptor P2Y12. The precise mechanisms remained poorly known.
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Recent results
We studied the metabolism of clopidogrel, one of the most anti-thrombotic drug prescribed in the world, by human liver microsomes (...)

 

 

 

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