Our team studies human upper limb motor control and in particular manual dexterity, as used in object grasp and object manipulation. This is pursued in healthy human subjects and in neurological and psychiatric patients. Methods
We combine complementary experimental and theoretical approaches :
Our behavioral studies (movement analysis) aim at the characterization of manual dexterity. Based on the quantitative description of upper limb motor behavior (movement kinematics and dynamics) we attempt to understand the constraints imposed by the neuronal substrate on dexterous function.
Our brain imaging and neurophysiological studies aim at directly characterizing the neural substrate : starting from the characterization of the neuronal substrate (including the degree of lesion or of plasticity in patients), we attempt to predict the behavioral consequences. This in particular concerns the clinical motor signs after injury (e.g. stroke) and the degree of spontaneous (if partial) recovery.
Our theoretical and neurorobotic approaches are means for (i) linking, testing and validating the relation between the neural substrate and its motor function beyond the correlations observed by experimentation, and (ii) for developing a Brain-Machine interface for the control of a robotic (and in the long term prosthetic) hand.
JL Mas – Centre de Psychiatrie et Neurosciences, Inserm U894, Paris.
MO Krebs – Centre de Psychiatrie et Neurosciences, Inserm U894, Paris.
T Brochier - Institut de Neurosciences de la Timone, Marseille.
RN Lemon - Institute of Neurology, UCL, UK.
J Borg - Karolinska Institutet/Danderyd Hospital,Stockholm.
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