Our lab is a new lab, which has started at Paris Descartes University in October 2012 and is also affiliated to the National Center for Scientific Research (CNRS – Federation de Recherche en Neurosciences FR3636), Faculty of Fundamental and Biomedical Sciences (UFR Biomedicale), Paris School of Neuroscience (Ecole des Neurosciences de Paris Ile-de-France, ENP), and the Institute of Neuroscience and Cognition of Paris Descartes (ICN).
We are interested in understanding the role of glial cells in the mammalian central nervous system and the mechanisms by which glial cells and neurons interact to support normal communication in the CNS.
We are developing and using a set of interdisciplinary and complementary tools and approaches (electrophysiology, pharmacogenetics, 2-photon Ca2+ imaging, immunohistochemistry, biochemistry, and behavior) to selectively manipulate glial cell signaling and investigate its effects in synaptic transmission and plasticity ex vivo and in vivo in different contexts (during sensory-activated synaptic transmission, development and neurodegenerative diseases).
From these studies, we hope to resolve some glial cell functions, and open up entirely new areas of investigation and potential treatments of brain diseases, e.g. neurodegenerative diseases or memory, sleep, and neuropsychiatric disorders.
Funding Agencies :
2012-2014 : Chair of Excellence from Paris School of Neuroscience (Ecole des Neurosciences de Paris - ENP ; http://www.paris-neuroscience.fr/en... )
2013-2017 : Marie Curie Career Integration Grant
2013-2015 : DIM Biotherapy from Ile-de-France Research Council
2014 -2016 : Medical Research Foundation (Fondation pour la Recherche Medicale – FRM)
|Bryan L. Roth Lab||Department of Pharmacology - University of North Carolina at Chapel Hill - NC - USA|
|Hsien-Sung Huang Lab||College of Medicine, National Taiwan University -Taiwan|
|Ken D. McCarthy Lab||Department of Pharmacology - University of North Carolina at Chapel Hill - NC – USA|
|Benjamin D. Philpot Lab||Department of Cell and Molecular Physiology - University of North Carolina at Chapel Hill - NC - USA|
|Mehdi Tafti Lab||Center for Integrative Genomics - University of Lausanne - Lausanne – Switzerland|
|Nicole Ropert/Martin Oheim Lab||INSERM U603, CNRS UMR 8118 – Paris Descartes University- Paris, France|